乏血供的早期非特殊型浸润性乳腺癌患者的临床病理特征

Clinical and pathological characteristics of early-stage breast cancer with poor blood supply

目的通过查找乳腺血管钙化的乳腺癌患者确定乏血供的早期非特殊型浸润性乳腺癌患者的临床病理特征。方法回顾性分析唐山市人民医院2018年1月1日—2023年5月1日确诊为早期非特殊型浸润性乳腺癌的女性患者,通过钼靶检查将之分为乳腺血管钙化组(BAC组)及非乳腺血管钙化组(nBAC组)。收集并比较二组患者的肿瘤T分期,Ki-67表达情况、组织学分级及分子分型。结果共收集符合条件的患者488例,其中BAC组患者79例,nBAC患者409例。发现与nBAC组患者比较,BAC组患者Luminal型比例较高,TNBC型及HER-2阳性型比例较低,差异有统计学意义(P=0.003)。BAC组患者肿瘤较小,Ki-67倾向低表达,组织学分级低,差异有统计学意义(P=0.016,<0.001,0.001,0.003)。整理绝经后BAC患者71人,绝经后nBAC患者187人。发现二组患者在肿瘤大小方面差异无统计学意义(P=0.118)。较nBAC组患者,BAC组患者的管型乳腺癌的比例较高,Ki-67低表达率较高,组织学分级更低,其差异均有统计学意义(P=0.007,0.002,0.002)。整理53~69岁的nBAC患者136例,将之与BAC患者比较发现,两者在肿瘤大小及分子分型中的差异无统计学意义(P=0.086,0.052)。但BAC患者仍有着Ki-67低表达率较高,组织学分级更低的特征(P=0.001,0.002)结论乏血供乳腺癌患者的肿瘤分化良好,增殖水平低,肿瘤恶性程度低。

Objective To identify the clinical and pathological characteristics of early non-special type invasive breast cancer patients with poor blood supply by examining breast arterial calcification in breast cancer patients. Methods A retrospective analysis was conducted on female patients diagnosed with early non-special type invasive breast cancer at Tangshan People's Hospital from January 1,2018 to May 1,2023.The patients were divided into two groups, Breast Arterial Calcification(BAC) group and non-Breast Arterial Calcification(nBAC) group based on molybdenum target examination.Tumor T staging, Ki-67 expression, histological grade, and molecular subtype were collected and compared between two groups. Results A total of four hundred and eighty-eight eligible patients were included, with 79 patients in BAC group and 409 patients in nBAC group.Compared to nBAC patients, BAC patients had a higher proportion of Luminal type and a lower proportion of TNBC type and HER-2 positive type, with statistically significant differences(P=0.003).BAC group had smaller tumors, lower Ki-67 expression tendency, and lower histological grade, all showing statistically significant differences(P=0.016,0.000,0.001,0.003).Among the postmenopausal patients, there were 71 BAC patients and 187 nBAC patients.There was no statistically significant difference in tumor size between two groups(P=0.118).Compared to nBAC patients, BAC group had a higher proportion of tubular breast cancer, higher rate of low Ki-67 expression, and lower histological grade, all showing statistically significant differences(P=0.007,0.002,0.002).Among nBAC patients aged 53 to 69,there were 136 cases.When compared to BAC patients, there was no statistically significant difference in tumor size and molecular subtype(P=0.086,0.052).However, BAC patients still exhibited features of higher rate of low Ki-67 expression and lower histological grade(P=0.001,0.002). Conclusion Breast cancer patients with poor blood supply exhibit well-differentiated tumors, low proliferation levels, and low malignancy.