耐碳青霉烯类肺炎克雷伯菌感染的治疗研究

Study on the treatment of carbapenem-resistant klebsiella pneumoniae infection

目的探讨耐碳青霉烯类肺炎克雷伯菌的抗感染治疗方案。方法回顾本院2020年2月-2021年6月住院患者检出CRKP的病例,应用SPSS软件比较CRKP患者治疗前后体温和感染标志物变化,结合病情,对治疗方案及疗效进行分析评价。结果研究纳入59名CRKP感染患者,药敏试验敏感率较高的药物有头孢他啶/阿维巴坦、替加环素、复方磺胺甲噁唑及多粘菌素。主要治疗方案为替加环素为基础的联合治疗,治疗有效率为72.88%。治疗前后患者体温、白细胞、中性粒细胞百分比和超敏C反应蛋白均较前明显下降,差异有统计学意义(P<0.05)。治疗过程中无明显不良反应发生。结论本院患者多使用替加环素联合方案治疗,疗效尚可。

Objective To investigate the anti-infective treatment of carbapenem-resistant Klebsiella pneumoniae(CRKP).Methods The cases of CRKP detected in hospitalized patients in our hospital from February 2020 to June 2021 were reviewed,we used SPSS software to compare the changes of body temperature and infection markers in CRKP patients before and after treatment,combined with the patient s clinical condition,analyzed and evaluated the treatment plan and efficacy.Results 59 patients with CRKP infection were enrolled in the study,ceftazidime/avibactam,tigacycline,compound sulfamethoxazole and polymyxin were the most sensitive drugs in drug susceptibility tests.The main treatment option was tigecycline-based combination therapy,and the effective rate was 72.88%.The body temperature,white blood cells,percentage of neutrophils and hypersensitive C-reactive protein of the patients were significantly decreased before and after treatment,the difference was statistically significant(P<0.05).There were no obvious adverse reactions during the treatment.Conclusions The patients in our hospital were treated with tigacycline combined regimen,and the effect was satisfactory.