洛拉替尼致不良反应的文献分析

Analysis on the literature of adverse reactions caused by Lorlatinib

目的分析洛拉替尼致ADR的发生情况及临床特点,为临床安全用药提供参考。方法通过检索PubMed、中国知网、万方和维普数据库,收集洛拉替尼致ADR的个案报道,并进行统计分析。结果共检索到洛拉替尼致ADR的文献报道13篇,15例患者共发生44例次ADR,男性7例,女性8例,56.82%的ADR在1 d~1个月内发生。ADR累及系统/器官主要涉及呼吸系统、中枢及外周神经系统等。结论临床使用洛拉替尼应加强监测,尤其是既往有肺部或脑部放疗史、颅脑转移、精神系统疾病以及正在服用相关药物患者,关注药物相互作用和疾病对药物的影响,警惕其ADR,以确保临床用药安全。

Objective:To analyze the occurrence and clinical features of adverse drug reactions(ADRs)of Lorlatinib,so as to provide reference for clinical safe medication.Methods Through searching Pubmed,CNKI and VIP databases,the case report of ADR caused by Lorlatinib were collected and analyzed statistically.Results A total of 13 literatures on ADR caused by Lorlatinib were searched,A total of 44 ADRs occurred in 15 patients,including 7 males and 8 females,56.82%of ADRs occurred eithin 1d to one month.ADR mainly involved respiratory system,central and peripheral nervous system.Conclusions We should strengthen monitoring for clinical use of Lorlatinib,especially in patients with a history of lung or brain radiotherapy,brain metastases,psychiatric disease and taking related drugs.Pay more attentions to drug interactions and disease effect on drugs,look sharp on the ADR to ensure clinical drug safety.