肌萎缩侧索硬化症患者营养管理的最佳证据总结

Summary of the best evidence for nutritional management in patients with amyotrophic lateral sclerosis

目的检索、评价和总结肌萎缩侧索硬化症(ALS)患者营养管理的最佳证据。方法采用PIPOST确定循证问题,按照“6S”证据检索模型自上而下依次检索国内外数据库及网站关于ALS患者营养管理的证据,检索时限为建库至2022年9月1日。由2名研究人员对纳入文献进行质量评价、证据提取及汇总。结果共纳入15篇文献,包括1篇临床决策、2篇指南、2篇系统评价、2篇随机对照试验、2篇队列研究、1篇专家共识和5篇专家意见,共提取出7个维度共28条证据。结论本研究对ALS患者营养管理最佳证据进行了总结,可为临床医护人员开展ALS患者营养管理提供循证依据。

Objective To review,evaluate,and summarize the best evidence of nutritional management in patients with amyotrophic lateral sclerosis(ALS).Methods PIPOST was used to determine evidence-based questions,and the evidence on nutritional management of ALS patients was successively searched in domestic and foreign databases and websites according to the 6S evidence search model from the establishment of the database to September 1,2022.Quality evaluation of the included literatures,extraction and summary of evidence were conducted by 2 researchers.Results A total of 15 literatures were included,including 1 clinical decision,2 guidelines,2 systematic reviews,2 randomized controlled trials,2 cohort studies,1 expert consensus,and 5 expert opinions.A total of 28 pieces of evidence from 7 aspects were extracted.Conclusion This study summarizes the best evidence of nutrition management in ALS patients,which can provides evidence-based basis for clinical medical staff to carry out nutrition management of ALS patients.