瑞马唑仑与丙泊酚对结肠镜检查患者术后认知功能及恢复质量的影响:临床比较研究

Effect of remimazolam versus propofol on postoperative cognitive function and quality of recovery in colonoscopy patients:a comparative clinical study

目的:探究瑞马唑仑与丙泊酚对结肠镜检查患者的术后认知功能及术后恢复质量的影响。方法:将150例结肠镜检查患者随机分为P组和R组,各75例。P组采用丙泊酚麻醉,R组采用苯磺酸瑞马唑仑麻醉。比较两组麻醉及苏醒时间、脑电双频指数(BIS)值、认知功能[蒙特利尔认知评估(MoCA)量表]、不良反应。结果:R组麻醉起效、检查结束至苏醒时间短于P组;用药5 min、置入肠镜时、置入肠镜5 min、术毕时的BIS值以及苏醒时的MoCA量表评分均高于P组;不良反应发生率低于P组(P<0.05)。结论:相较丙泊酚,瑞马唑仑用于结直肠镜检查患者的麻醉效果较好,且对患者BIS值及认知功能影响较小,更利于患者术后恢复,安全性较高。

Objective:To investigate the clinical effects of remimazolam and propofol on postoperative cognitive function and recovery quality in colonoscopy patients.Methods:One hundred and fifty patients undergoing colonoscopy were randomly divided into group P and group R,with 75 cases each.Group P was anesthetized with propofol,while group R was anesthetized with remimazolam benzenesulfonate.The time for anesthesia and awakening,bispectral index(BIS)value,cognitive function[Montreal cognitive assessment(MoCA)scale]and adverse reactions were compared between the two groups.Results:The onset of anesthesia and the time from the end of the examination to awakening were shorter,the BIS values at 5 min of medication,at the time of colonoscopy placement,at 5 min of colonoscopy placement,and at the end of the procedure,as well as the MoCA scale scores at the time of awakening were higher,and the incidence of adverse reactions was lower in the group R than the group P(P<0.05).Conclusion:Compared with propofol,remimazolam is more effective in anesthesia for patients with colonoscopy and has less effect on patients’BIS value and cognitive function,which is more conducive to patients’postoperative recovery and safer.