叶酸对妊娠期高血压疾病的作用机制研究进展

Research progress on the mechanism of action of folic acid on gestational hypertension

妊娠期高血压疾病是妊娠期间发病率最高的并发症,伴随早产、胎儿生长受限、胎盘过早分离、宫内死亡等多种风险,甚至导致孕妇和胎儿死亡。叶酸水平低是发生妊娠期高血压疾病的重要危险因素,服用叶酸可降低其发生风险,并降低不良妊娠结局发生风险,但具体机制还有待研究。本文就叶酸对妊娠期高血压疾病的作用机制研究进展进行综述,为临床研究提供参考。

Hypertensive disorder complicating pregnancy is a complication with the highest incidence rate during pregnancy,which is accompanied by premature delivery,fetal growth restriction,premature separation of placenta,intrauterine death and other risks,and even leads to maternal and fetal death.Low folate levels are an important risk factor for the development of gestational hypertension,and taking folate can reduce its risk and lower the risk of adverse pregnancy outcomes.However,the specific mechanism remains to be studied.This article reviews the research progress on the mechanism of action of folic acid on gestational hypertension,providing reference for clinical research.