低分子肝素钠联合拉贝洛尔治疗妊娠期高血压疾病的效果

The effect of low molecular weight heparin sodium combined with labetalol in the treatment of gestational hypertension

目的探讨低分子肝素钠联合拉贝洛尔治疗妊娠期高血压疾病的效果。方法选取本院收治的60例妊娠期高血压疾病患者为研究对象,按照随机数字表法分为两组,各30例。对照组应用拉贝洛尔治疗,试验组应用低分子肝素钠联合拉贝洛尔治疗,比较两组治疗前后的妊娠期高血压相关指标、子宫血流动力学指标及胎盘生长因子水平。结果治疗后,试验组平均动脉压、血尿素氮、尿酸、收缩压、舒张压水平均低于对照组,差异有统计学意义(P<0.05);治疗后,试验组搏动指数、阻力指数、脐动脉收缩压与舒张压比值均低于对照组,差异有统计学意义(P<0.05);治疗后,试验组妊娠相关血浆蛋白A水平低于对照组,血管内皮细胞生长因子、胎盘生长因子水平高于对照组,差异有统计学意义(P<0.05)。结论低分子肝素钠联合拉贝洛尔治疗妊娠期高血压疾病,可有效改善患者的血压相关指标、子宫血流动力学指标及胎盘生长因子水平,值得推广。

Objective To explore the effect of low molecular weight heparin sodium combined with labetalol in the treatment of gestational hypertension.Methods 60 patients with gestational hypertension admitted to our hospital were selected as the research subjects,and were randomly divided into two groups,each with 30 cases,using a random number table method.The control group was treated with labetalol,while the experimental group was treated with a combination of low-molecular-weight heparin sodium and labetalol.The pregnancy induced hypertension related indicators,uterine hemodynamic indicators,and placental growth factor levels before and after treatment were compared between the two groups.Results After treatment,the average arterial pressure,blood urea nitrogen,uric acid,systolic blood pressure,and diastolic blood pressure in the experimental group were lower than those in the control group,with statistical significance(P<0.05);After treatment,the pulsatile index,resistance index,and ratio of umbilical artery systolic and diastolic pressure in the experimental group were all lower than those in the control group,and the differences were statistically significant(P<0.05);After treatment,the pregnancy related plasma protein A levels in the experimental group were lower than those in the control group,while the levels of vascular endothelial growth factor and placental growth factor were higher than those in the control group,with statistical significance(P<0.05).Conclusion The combination of low molecular weight heparin sodium and labetalol can effectively improve blood pressure related indicators,uterine hemodynamic indicators,and placental growth factor levels in patients with gestational hypertension.It is worth promoting.