聚肌胞注射液联合更昔洛韦眼用凝胶治疗眼部带状疱疹的疗效

Efficacy of Polyinosinic:Polycytidylic Acid Copolymer Combined with Ganciclovir Ophthalmic Gel in the Treatment of Ocular Herpes Zoster

目的研究聚肌胞注射液联合更昔洛韦眼用凝胶治疗眼部带状疱疹的疗效。方法以2021年10月-2023年2月天津市眼科医院收治的100例眼部带状疱疹患者为研究对象,经随机数字表法分为对照组与观察组,各50例。对照组给予更昔洛韦眼用凝胶治疗,观察组采用聚肌胞注射液联合更昔洛韦眼用凝胶治疗,比较两组临床疗效、症状消退时间(肿胀、疱疹、眼部刺激)、疼痛程度[视觉模拟评分(VAS)]、疱疹创面愈合时间及不良反应发生情况。结果观察组治疗总有效率为88.00%,高于对照组的72.00%(P<0.05);观察组肿胀、疱疹、眼部刺激症状消退时间短于对照组(P<0.05);两组治疗后VAS评分低于治疗前,且观察组VAS评分低于对照组(P<0.05);观察组疱疹创面愈合时间短于对照组(P<0.05);观察组不良反应发生率与对照组比较,差异无统计学意义(P>0.05)。结论聚肌胞注射液联合更昔洛韦眼用凝胶治疗眼部带状疱疹的疗效确切,可促进症状消退,减轻患者疼痛,加速创面愈合,用药安全性佳。

Objective To study the efficacy of polyinosinic:polycytidylic acid copolymer combined with ganciclovir ophthalmic gel in the treatment of ocular herpes zoster.Methods A total of 100 patients with ocular herpes zoster admitted to Tianjin Eye Hospital from October 2021 to February 2023 were divided into control group and observation group by random number table method,with 50 patients in each group.The control group was treated with ganciclovir ophthalmic gel,and the observation group was treated with polyinosinic:polycytidylic acid copolyme combined with ganciclovir ophthalmic gel.The clinical efficacy,symptom regression time(swelling,herpes,eye stimulation),pain degree[Visual Analogue Scale(VAS)],herpes wound healing time and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 88.00%,which was higher than 72.00% in the control group(P<0.05).The time of swelling,herpes,eye irritation symptom regression in the observation group was shorter than that in the control group(P<0.05).The VAS score of the two groups after treatment was lower than that before treatment,and the VAS score of the observation group was lower than that of the control group(P<0.05).The healing time of herpes wound in the observation group was shorter than that in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the observation group and the control group(P>0.05).Conclusion Polyinosinic:polycytidylic acid copolymer combined with ganciclovir ophthalmic gel is effective in the treatment of ocular herpes zoster,which can promote the regression of symptoms,reduce the pain degree,accelerate wound healing,and has good drug safety.