肠道益生菌联合小儿豉翘清热颗粒对手足口病患儿炎症指标的影响

Effect of Intestinal Probiotics Combined with Xiao'er Chiqiao Qingre Granules on Inflammatory Indexes in Children with Hand-foot-mouth Disease

目的研究肠道益生菌(IP)联合小儿豉翘清热颗粒治疗手足口病的临床效果。方法选取2020年10月-2022年10月泰和县人民医院收治的60例手足口病患儿,按照随机数字表法分为对照组(30例)与观察组(30例),对照组给予小儿豉翘清热颗粒治疗,观察组在其基础上加用肠道益生菌治疗,比较两组临床疗效、症状消退时间(热退时间、胃肠道症状消退时间、皮疹消失时间)、血常规[白细胞计数(WBC)、中性粒细胞比率(NEU)]及炎症指标水平[C-反应蛋白(CRP)、血清淀粉蛋白A(SAA)]。结果观察组总有效率较对照组高(P<0.05);观察组症状消退时间(热退时间、胃肠道症状消退时间、皮疹消失时间)短于对照组(P<0.05)。两组治疗后WBC、NEU水平均低于治疗前,且观察组WBC、NEU低于对照组(P<0.05)。两组治疗后CRP、SAA均低于治疗前,且观察组CRP、SAA低于对照组(P<0.05)。结论肠道益生菌联合小儿豉翘清热颗粒可提高手足口病的治疗效果,加快症状消退,对患儿血常规及炎症指标具有积极改善作用。

Objective To study the clinical effect of intestinal probiotics(IP)combined with Xiao’er Chiqiao Qingre granules in the treatment of hand-foot-mouth disease.Methods Sixty children with hand-foot-mouth disease admitted to Taihe County People's Hospital from October 2020 to October 2022 were selected and divided into control group(30 children)and observation group(30 children)according to the random number table method.The control group was treated with Xiao'er Chiqiao Qingre granules,and the observation group was treated with intestinal probiotics on the basis of the control group.The clinical efficacy,symptom regression time(fever regression time,gastrointestinal symptom regression time,rash disappearance time),blood routine[white blood cell count(WBC),neutrophil ratio(NEU)]and inflammatory index levels[C-reactive protein(CRP),serum amyloid A(SAA)]were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group(P<0.05).The symptom regression time(heat regression time,gastrointestinal symptom regression time,rash disappearance time)in the observation group was shorter than that in the control group(P<0.05).After treatment,the levels of WBC and NEU in the two groups were lower than those before treatment,and the levels of WBC and NEU in the observation group were lower than those in the control group(P<0.05).After treatment,CRP and SAA in the two groups were lower than those before treatment,and CRP and SAA in the observation group were lower than those in the control group(P<0.05).Conclusion Intestinal probiotics combined with Xiao'er Chiqiao Qingre granules can improve the therapeutic effect of hand-foot-mouth disease,accelerate the regression of symptoms,and have a positive effect on blood routine and inflammatory indicators in children.