拉贝洛尔联合硝苯地平对妊娠期高血压患者的临床治疗效果分析

Clinical effect analysis of labetalol combined with nifedipine on patients with pregnancy induced hypertension

目的分析拉贝洛尔联合硝苯地平对妊娠期高血压患者的临床治疗效果。方法110例妊娠期高血压患者,按治疗方法差异分为观察组(50例)和对照组(60例)。观察组使用拉贝洛尔联合硝苯地平治疗,对照组单用拉贝洛尔治疗。对比两组临床疗效、不良妊娠结局、血压[收缩压(SBP)、舒张压(DBP)]、尿蛋白指标[24 h尿蛋白定量(24 h U-Pro)]及C反应蛋白(CRP)和胎盘生长因子(PLGF)。结果观察组治疗总有效率为94.00%,明显高于对照组的76.67%(P<0.05)。观察组治疗后SBP(116.24±7.37)mm Hg(1 mm Hg=0.133 kPa)、DBP(81.63±6.16)mm Hg、24 h U-Pro(0.92±0.18)g/24 h均低于对照组的(134.05±9.21)mm Hg、(90.74±6.57)mm Hg、(1.75±0.27)g/24 h(P<0.05)。观察组治疗后CRP水平(8.15±1.33)mg/L明显低于对照组的(12.28±1.87)mg/L,PLGF水平(220.79±21.48)pg/ml明显高于对照组的(149.62±17.37)pg/ml(P<0.05)。观察组不良妊娠结局(胎儿宫内窘迫、新生儿窒息、胎盘早剥、羊水Ⅲ度浑浊、早产、产后出血)发生率18.00%明显低于对照组的45.00%(P<0.05)。结论拉贝洛尔联合硝苯地平对妊娠期高血压患者的临床治疗效果显著,能有效控制血压及蛋白尿,减轻炎症反应,保护胎盘功能,降低不良妊娠结局发生率。

Objective To analyze the clinical effect of labetalol combined with nifedipine on patients with pregnancy induced hypertension.Methods 110 patients with pregnancy induced hypertension were divided into an observation group(50 cases)and a control group(60 cases)according to the difference of treatment methods.The observation group was treated with labetalol combined with nifedipine,and the control group was treated with labetalol alone.Both groups were compared in terms of clinical efficacy,adverse pregnancy outcome,blood pressure[systolic blood pressure(SBP),diastolic blood pressure(DBP)],urinary protein markers[24 h urinary protein(24 h U-Pro)],C-reactive protein(CRP)and placental growth factor(PLGF).Results The total effective rate of the observation group was 94.00%,which was significantly higher than 76.67%of the control group(P<0.05).After treatment,the observation group had SBP of(116.24±7.37)mm Hg(1 mm Hg=0.133 kPa),DBP of(81.63±6.16)mm Hg,and 24 h U-Pro of(0.92±0.18)g/24 h,which were lower than(134.05±9.21)mm Hg,(90.74±6.57)mm Hg,and(1.75±0.27)g/24 h in the control group(P<0.05).After treatment,the observation group had significantly lower CRP level of(8.15±1.33)mg/L than(12.28±1.87)mg/L in the control group,and significantly higher PLGF level of(220.79±21.48)pg/ml than(149.62±17.37)pg/ml in the control group(P<0.05).The incidence of adverse pregnancy outcomes(intrauterine distress,neonatal asphyxia,placental abruption,Ⅲdegree of amniotic fluid turbidity,premature delivery and postpartum hemorrhage)in the observation group was 18.00%,which was significantly lower than 45.00%in the control group(P<0.05).Conclusion Labetalol combined with nifedipine has significant clinical effect on patients with pregnancy induced hypertension,and can effectively control blood pressure and proteinuria,reduce inflammation,protect placental function,and lower the incidence of adverse pregnancy outcomes.