县级市高邮地区2019-2022年尿路感染病原菌分析

Analysis of pathogenic bacteria of urinary tract infection in Gaoyou area from 2019 to 2022

目的分析高邮地区2019-2022年尿路感染病原菌分布及药物敏感性,为临床合理使用抗菌药物提供可靠依据和抗感染治疗提供参考。方法选取2019年1月20日-2022年12月20日高邮市人民医院临床住院和门诊患者送检的尿培养标本中分离的3186株病原菌进行研究,比较主要病原菌分布情况、药物敏感试验情况。结果3186株尿培养阳性病原菌中,构成比位居前10位的分别为大肠埃希菌(47.68%)、肺炎克雷伯菌(7.47%)、粪肠球菌(7.25%)、屎肠球菌(5.78%)、奇异变形杆菌(3.01%)、表皮葡萄球菌(2.64%)、铜绿假单胞菌(2.26%)、阴沟肠杆菌(1.6%)、溶血葡萄球菌(1.38%)、产气肠杆菌(1.22%)。不同性别的尿路感染主要致病菌分布不同:大肠埃希菌的检出率女性高于男性(58.49%VS29.81%),而铜绿假单胞菌的感染率则男性高于女性(4.75%VS0.76%)。且大肠埃希菌与肺炎克雷伯菌的耐药率随着年龄的增加有趋于严重的趋势。结论尿路感染的病原菌对不同抗菌药物的药物敏感率不同,因此临床需加强耐药菌监测,定期监测和分析当地患者尿培养病原菌种类及药物敏感性,临床可以根据当地的病原菌分布及药物敏感性特点早期用药。

Objective The distribution of pathogenic bacteria and drug sensitivity analysis of urinary tract infection in Gaoyou area from 2019 to 2022 were analyzed,which provided a reliable basis for the rational use of anti-inflammatory drugs and anti-infective treatment in clinical use.Methods From January 20,2019 to December 20,2022,3186 pathogenic bacteria isolated from urine culture samples sent by clinical inpatients and outpatients in Gaoyou People's Hospital were selected for study,and the distribution of major pathogenic bacteria and drug susceptibility test were compared.Results Among the 3186 cases of pathogens with positive urine culture,the composition ratio of the top 10 were Escherichia coli(47.68%),Klebsiella pneumoniae(7.47%),Enterococcus faecaliensis(7.25%),Enterococcus faecium(5.78%),Proteus(3.01%),Staphylococcus(2.64%),Pseudomonas aeruginosa(2.26%),Enterobacter cloacae(1.6%),Staphylococcus hemolyticus(1.38%),and Enterobacter aerogenes(1.22%).The distribution of the main pathogenic bacteria of urinary tract infection was different in different sexes:the detection rate of Escherichia coli was higher in women than in men(58.49%vs.29.81%),while the infection rate of patina was higher in males than in females(4.75%vs.0.76%).The resistance rate of Escherichia coli and Klebsiella pneumoniae tended to be serious with age.Conclusion The pathogenic bacteria of urinary tract infection have different drug sensitivity rates to different antibacterial drugs,so it is necessary to strengthen the monitoring of drug-resistant bacteria clinically,regularly monitor and analyze the types of pathogenic bacteria and drug sensitivities in urine culture of local patients,and use drugs early according to the local pathogenic bacteria cloth and drug sensitivity characteristics.