694 nm调Q红宝石点阵激光联合氨甲环酸治疗黄褐斑的临床效果观察

Observation on the Clinical Effect of 694 nm Q-Switched Ruby Lattice I aser Combined with Tranexamic Acid in the Treatment of Melasma

目的探讨694 nm调Q红宝石点阵激光联合氨甲环酸治疗黄褐斑的临床效果。方法62例黄褐斑患者随机分为两组。对照组采用氨甲环酸胶囊治疗,研究组在对照组基础上采用694 nm调Q红宝石点阵激光治疗。比较两组的疗效、黄褐斑症状、不良反应及复发率。结果研究组的治疗总有效率为96.77%,显著高于对照组的80.65%(P<0.05)。治疗后,研究组的MASI评分显著低于对照组(P<0.05)。治疗期间,两组均无明显不良反应发生。研究组的复发率为3.23%,显著低于对照组的22.58%(P<0.05)。结论694 nm调Q红宝石点阵激光联合氨甲环酸治疗黄褐斑的效果显著,可明显降低患者的MASI评分和复发率。

Objective To explore the clinical effect of 694 nm Q-switched ruby lattice laser combined with tranexamic acid in the treatment of melasma.Methods 62 patients with melasma were randomly divided into two groups.The control group was treated with tranexamic acid capsules,and the study group was treated with 694 nm Q-switched ruby lattice laser on the basis of the control group.The efficacy,melasma symptoms,adverse reactions and recurrence rate were compared between the two groups.Results The total effective rate of treatment of the study group was 96.77%,significantly higher than 80.65%of the control group(P<0.05).After treatment,the MASI score of the study group was significantly lower than that of the control group(P<0.05).During the treatment,no obvious adverse reaction occurred in the two groups.The recurrence rate of the study group was 3.23%,significantly lower than 22.58%of the control group(P<0.05).Conclusions 694 nm Q-switched ruby lattice laser combined with tranexamic acid in the treatment of melasma has significant effect,which can obviously reduce the MASI score and recurrence rate of patients.