补益脾胃溃结方对脾胃虚弱型溃疡性结肠炎患者的临床疗效

Clinical effects of Buyi Piwei Kuijie Recipe on patients with ulcerative colitis due to Spleen-Stomach Weakness

目的 探讨补益脾胃溃结方对脾胃虚弱型溃疡性结肠炎患者的临床疗效。方法 132例患者随机分为对照组和观察组,每组66例,对照组给予常规治疗,观察组在对照组基础上加用补益脾胃溃结方,疗程4周。检测临床疗效、Mayo评分、SF-36评分、中医证候评分、5-HT、IL-6、TNF-α、IL-4、CD4^(+)/CD8^(+)、LPS、TGF-β1、DAO变化。结果 观察组总有效率高于对照组(P<0.05)。治疗后,2组Mayo评分、中医证候评分、TNF-α、LPS、5-HT、IL-6、CD4^(+)/CD8^(+)、DAO降低(P<0.05),SF-36评分、TGF-β1、IL-4升高(P<0.05),以观察组更明显(P<0.05)。结论 补益脾胃溃结方可减轻脾胃虚弱型溃疡性结肠炎患者炎症反应,调节免疫功能,抑制疼痛介质分泌,促进肠黏膜修复,提高临床疗效。

AIM To explore the clinical effects of Buyi Piwei Kuijie Recipe on patients with ulcerative colitis due to Spleen-Stomach Weakness.METHODS One hundred and thirty-two patients were randomly assigned into control group(66 cases)for 4-week intervention of conventional treatment,and observation group(66 cases)for 4-week intervention of both Buyi Piwei Kuijie Recipe and conventional treatment.The changes in clinical effects,Mayo score,SF-36 score,TCM syndrome score,5-HT,IL-6,TNF-α,IL-4,CD4^(+)/CD8^(+),LPS,TGF-β1,and DAO were detected.RESULTS The observation group demonstrated higher total effective rate than the control group(P<0.05).After the treatment,the two groups displayed decreased Mayo score,TCM syndrome score,TNF-α,LPS,5-HT,IL-6,CD4^(+)/CD8^(+),DAO(P<0.05),and increased SF-36 score,TGF-β1,IL-4(P<0.05),especially for the observation group(P<0.05).CONCLUSION For the patients with ulcerative colitis due to Spleen-Stomach Weakness,Buyi Piwei Kuijie Recipe can reduce inflammatory reactions,regulate immune functions,inhibit pain medium secretion,promote intestinal mucosa repair,and enhance clinical effects.