肿瘤终末期姑息化疗与非化疗治疗的临床效果比较

Comparative analysis of clinical effects of palliative chemotherapy and non-chemotherapy treatment in end-stage tumor

目的分析姑息化疗和非化疗治疗在终末期肿瘤患者中的临床效果。方法选取2020年12月—2021年12月本院收治的90例终末期肿瘤患者,根据患者和家属主观意愿将其分为研究组与对照组,每组各45例。研究组行姑息化疗,对照组行非化疗治疗,评价两组临床疗效。结果研究组不良情绪及生活质量评分均优于对照组(t=12.810、11.562、6.898、9.864、6.543、10.442,均P<0.05),治疗总有效率、疾病控制率、各不良反应发生率均高于对照组(χ^(2)=4.500、9.360、4.555、4.121、4.727、4.464,均P<0.05)。结论对终末期肿瘤患者实施姑息化疗可提高疾病控制效果,改善生活质量,但医疗费用及不良反应较高;而非化疗治疗可改善患者不良情绪。因此,临床应依据患者或家属意愿选择治疗方案。

Objective To analyze the clinical effects of palliative chemotherapy and non-chemotherapy treatment in patients with end-stage tumor.Methods A total of 90 end-stage tumor patients treated at our hospital from December 2020 to December 2021.Based on the subjective wishes of the patients and their families,they were divided into a study group and a control group,with 45 patients in each.The study group underwent palliative chemotherapy,while the control group received non-chemotherapy treatment.The clinical effectiveness of both groups was evaluated.Results The study group showed better scores in emotional distress and quality of life than the control group(t=12.810,11.562,6.898,9.864,6.543,10.442,all P<0.05).However,an overall effectiveness rate,disease control rate,and the incidence of adverse reactions were higher in the study group(χ^(2)=4.500,9.360,4.555,4.121,4.727,4.464,all P<0.05).Conclusion Palliative chemotherapy in end-stage tumor patients can improve disease control and quality of life,but it comes with higher medical costs and adverse reactions.Non-chemotherapy treatment,on the other hand,can improve emotional distress.Therefore,treatment plans should be chosen based on the patient or family's wishes.