某品牌灵芝破壁孢子粉的安全性评价

Safety assessment of a wall-broken Ganoderma lucidum spore powder

目的研究某品牌灵芝破壁孢子粉的安全性。方法采用急性毒性试验、3项遗传毒性试验和30 d喂养试验评价灵芝破壁孢子粉的安全性。结果该品牌灵芝破壁孢子粉对小鼠急性经口MTD值>15000 mg/kg b.wt,属无毒级;3项遗传毒性试验均为阴性结果;30 d喂养期间,不同剂量的灵芝破壁孢子粉对大鼠的体重、食物利用率、主要脏体、血液学和血生化指标均产生显著影响(P值均<0.05);试验动物组织病理学均未见显著改变。结论试验条件下,该品牌灵芝破壁孢子粉的安全性良好。

Objective To assess the safety of a wallbroken Ganoderma lucidum spore powder.Methods The safety of a wall-broken Ganoderma lucidum spore powder was evaluated through acute toxicity test,three genetic toxicity tests and 30-day feeding test.Results The oral maximum tolerated dose of this wall-broken Ganoderma lucidum spore powder was>15000 mg/kg body weight in mice,belonging to the non-toxic grade,and all three genetic toxicity tests were negative.During the 30-day feeding period,the dose of this wall-broken Ganoderma lucidum spore powder had significant impacts on the body weight,food utilization rate,main visceral body,and hematological and blood biochemical parameters of rats(all P values<0.05).In addition,no remarkable changes were seen in the pathology of animal tissues.Conclusions The wall-broken Ganoderma lucidum spore powder has a high safety under experimental conditions.