基于肝“阴阳失和”探究从肝论治心理生理性失眠

Theoretical studyyonliver-based treatmentofI psychophysiological insomnia through the lens of liver yin-yang imbalance

因心理、环境等因素造成的心理生理性失眠(psychophysiological insomnia, PSY-I)已严重影响大众的生活与工作,而且成为了威胁人类健康的“隐形杀手”,探究本病的发病机制及进行明确的辨证用药具有重要的应用意义。本文认为心理生理性失眠的核心病机是肝“阴阳(体用)失和”,并突出“Glu-SCN-GABA网络”及相关神经肽类物质调节失衡的发病机制与肝“阴阳(体用)失和”的核心病机相吻合的特点,进而形成基于肝“阴阳(体用)失和”论治PSY-I的治疗理念,为失眠病理机制研究的突破,以及为失眠的预警诊断提供新的依据。

Psychophysiological insomnia(PSY-I),caused by psychological and environmental factors,significantly impacts people's lives and work,emerging as an"invisible killer"threatening human health.Exploring the pathogenesis of this condition and clearly identifying the syndrome differentiation and treatment principles are of great practical significance.This article posits that the core pathogenesis of PSY-I is the imbalance of yin-yang(substance-function)of the liver,and it highlights the characteristics of the Glu-SCN-GABA network and the imbalance of relevant neuropeptides in the pathogenesis,which are consistent with the core pathogenesis of the liver's yin-yang(substance-function)imbalance.This lays the foundation for a treatment concept based on the theory of liver yin-yang(substance-function)imbalance for addressing PSY-I,which will become a new breakthrough in the research of insomnia pathogenesis and provide new basis for the early warning diagnosis of insomnia.