口服益生菌对妊娠期阴道炎患者阴道菌群的影响

Effect of oral probiotics on vaginal microbiota in patients with vaginitis during pregnancy

目的评价口服含4种乳杆菌菌株的益生菌胶囊对妊娠期阴道炎患者阴道菌群的影响及辅助治疗效果。方法共纳入395例,对照组(n=171,抗生素),接受7 d抗生素治疗。联合组(n=224,抗生素+益生菌),抗生素与益生菌联合应用7 d后,继续每天口服1粒益生菌,共28 d。两组患者在研究入组和第28天时各接受1次阴道菌群检查及临床效果评估,比较两组阴道乳杆菌变化和辅助治疗效果。结果两组患者阴道乳杆菌比例和疗效差异明显(P<0.05),联合组和对照组有效率分别为90.2%、86.0%,治愈率分别为30.4%、19.3%。结论口服含乳杆菌菌株的益生菌可以增加妊娠期阴道炎患者阴道乳杆菌比例,辅助治疗妊娠期阴道炎效果良好。

Objective To evaluate the effect of oral probiotics containing 4 strains of lactobacillus on the vaginal microbiota and adjuvant treatment effect of patients with vaginitis during pregnancy.Methods A total of 395 cases were included,171 cases in the control group received 7 days of antibiotic treatment,and 224 cases in the combined treatment group.After the combined use of antibiotics and probiotics for 7 days,they continued to take 1 probiotic pill daily for the 28th day.The patients received a vaginal microecological examination and clinical evaluation at study entry and 28 days to compare the vaginal lactobacillus between the two groups.Results There was a statistical difference in the proportion of vaginal lactobacillus and the efficacy of treatment between the two groups of patients(P<0.05).The effective rates in the combined treatment group and the control group were 90.2%and 86.0%respectively,and the cure rates were 30.4%and 19.3%respectively.Conclusions Oral probiotics containing lactobacillus strains can increase the proportion of vaginal lactobacillus in patients with vaginitis during pregnancy which significantly facilitated the clinical treatment of vaginitis during pregnancy.