《尤氏喉科秘书》治疗喉症肿痛闭塞外用吹药使用规律探析

Analysis on the rules of application of insufflation of powder drug in the treatment of laryngeal swelling,pain and occlusion in Youshi Houke Mishu

目的:使用数据挖掘技术探究《尤氏喉科秘书》外用吹药治疗喉症之肿痛闭塞的药物使用规律。方法:选取符合纳入标准的吹药方剂,利用WPS Office 2023、SPSS Statistics 25.0和SPSS Molder 18.0软件建立数据库并对其进行频次统计分析、关联规则分析、网络链接分析、聚类分析等,挖掘用药规律。结果:共纳入处方19首,涉及药物43味,药物使用总频次137次,使用频次≥3次的药物共有14味,分别是冰片、薄荷、甘草、白矾、硼砂、儿茶、芒硝、蒲黄、青黛等;使用频次较高的药物类别是开窍药、解表药、活血化瘀药、清热药;关联规则分析共得到关联规则236条;聚类分析将距离定为20,共得4组药对。C1:儿茶、珍珠、龙骨、黄连、黄柏,用于清热凉血,活血化瘀。C2:白矾、牛黄,主要作用为清热涤痰,止血止痛。C3:冰片、蒲黄,主要功效为活血行瘀,解毒止痛。C4:薄荷、青黛、硼砂、芒硝、甘草,主要功效为清热消痰,散结止痛。结论:《尤氏喉科秘书》治疗喉疾以“辛凉清火,活血化痰”为治疗大法,以“标本兼顾,随症加减”为治疗根本,具有一人一方、因人治宜的优势,值得深入挖掘。

Objective:To explore the medication application rules of insufflation of powder drug in the treatment of laryngeal swelling,pain and occlusion in Youshi Houke Mishu by using data mining technology.Methods:The prescriptions of insufflation of powder drug that met the inclusion criteria were selected.WPS Office2023,SPSS Statistics 25.0 and SPSS Molder 18.0 were used to establish a database,and the frequency statistical analysis,association rule analysis,network link analysis,cluster analysis,etc.,were carried out to discover the medication application rules.Results:A total of 19 prescriptions were included,involving 43 drugs.The total frequency of drug use was 137 times,and there were 14 drugs used more than 3 times,including Bingpian,Bohe,Gancao,Baifan,Pengsha,Ercha,Mangxiao,Puhuang,Qingdai,etc.The most frequently used were awaking drugs,drugs for relieving exterior disorder,drugs for promoting blood circulation and removing blood stasis,and drugs for clearing heat.A total of 236 association rules were obtained by association rule analysis.In cluster analysis,the distance was set as 20,and a total of 4 groups of couplet medicines were obtained,namely.C1:Ercha,Zhenzhu,Longgu,Huanglian,and Huangbai,which were used for clearing heat and cooling blood,promoting blood circulation and removing blood stasis.C2:Baifan and Niuhuang,which were mainly used for clearing heat and eliminating phlegm,stopping bleeding and relieving pain.C3:Bingpian and Puhuang,which were used for promoting blood circulation and removing blood stasis,detoxification and relieving pain.C4:Bohe,Qingdai,Pengsha,Mangxiao and Gancao,which were used for clearing heat and removing phlegm,dissipating stagnation and relieving pain.Conclusion:In the treatment of laryngeal diseases in Youshi Houke Mishu,the main method is“clearing the fire with pungent and cool drugs,activating blood and dissipating phlegm”,and the fundamental principle for treatment is“taking both root cause and manifestations into account,modifying the prescription according to the symptoms”,which have the advantages of treatment chosen according to the variability of an individual,and are worth further exploration.