天然高分子自组装包埋单细胞在生物医学领域的应用

Self-assembly of Natural Polymer-embedded Single Cells for Biomedical Applications

利用层层自组装法制备天然高分子功能材料,具有操作简单、反应条件温和、壳层结构易调等特点,近年来已成为热点研究方向之一。基于此,本综述总结了利用淀粉、壳聚糖、海藻酸钠、明胶、纤维素等天然高分子,通过层层自组装法制备单细胞壳层的策略,讨论了自组装过程对细胞活性、pH耐受性等性能的影响,为固定化细胞在生物医学领域中的应用提供参考。

Layer-by-Layer self-assembly method for preparation of natural polymer functionalized materials has emerged as a promising re-search direction in recent years,owing to its straight forward operation,gentle reaction conditions,and flexibility in adapting the shell layer structure.This review outlined the use of natural polymers like starch,chitosan,sodium alginate,gelatine,and cellulose to create single-cell shell layers through electrostatic Layer-by-Layer self-assembly.It also discussed the impact of the self-assembly process on the properties such as cell activity and pH tolerance,offering insight into the potential application of immobilized cells in biomedicine.