青少年抑郁症患者自伤行为与甲状腺激素和脂类的关系

Relation of self-injury behavior to thyroid hormones and lipids in adolescent patients with depression

目的:探讨青少年抑郁症患者的自伤行为与正常范围内甲状腺激素与脂类的关系。方法:纳入符合精神障碍诊断与统计手册第5版(DSM-5)抑郁症诊断标准的青少年住院患者182例,其中伴自伤行为38例,不伴自伤行为144例。比较两组各指标的差别,用logistic回归分析青少年抑郁症患者自伤的相关因素。结果:青少年抑郁症患者中伴自伤行为组的总胆固醇、高密度脂蛋白胆固醇水平高于不伴自伤行为组(P<0.05),游离甲状腺素水平低于不伴自伤行为组(P<0.05)。Logistic回归分析结果显示病程时间(OR=1.03)越长、高密度脂蛋白胆固醇越高(OR=12.75)的青少年抑郁症患者越容易有自伤行为。结论:病程时间长、高密度脂蛋白胆固醇水平高可能是青少年抑郁症自伤行为发生的危险因素,游离甲状腺素水平低可能是保护因素。

Objective:To explore the relation of self-injury behavior to thyroid hormones and lipids in adoles-cent patients with depression.Methods:A total of 182 adolescent inpatients who met the diagnostic criteria for de-pression according to the Diagnostic and Statistical Manual of Mental Disorders,Fifth Edition(DSM-5)were en-rolled,including 38 cases with self-injurious behavior and 144 cases without self-injurious.The differences in vari-ous indicators between the two groups were compared,and logistic regression analysis was used to analyze factors related to self-injury in adolescents with depression.Results:The patients with self-injurious behavior had higher levels of total cholesterol and high-density lipoprotein cholesterol(HDL-C)compared to those without self-injuri-ous behavior(P<0.05).They also had lower levels of free thyroxine compared to the group without self-injurious behavior(P<0.05).Logistic regression analysis results showed that those with longer duration of disease(OR=1.03)and higher HDL-C levels(OR=12.75)were more likely to have self-injurious behaviors.Conclusion:Long duration of disease and high level of HDL-C may be risk factors for self-injurious behavior in adolescents with de-pression,while low level of free thyroxine may serve as a protective factor.