1990—2019年归因于高BMI的痴呆症疾病负担分析

Disease burden of dementia attributed to high BMI in 1990-2019

目的了解1990—2019年中国归因于高BMI的痴呆症疾病负担变化趋势,为制定痴呆症防控策略提供依据。方法利用2019全球疾病负担研究(Global Burden of Disease Study 2019,GBD 2019)中有关数据,采用死亡数、伤残调整寿命年(disability adjusted life years,DALYs)、伤残损失寿命年(years lived with disability,YLDs)、过早死亡损失寿命年(years of life lost,YLLs)及其标化率等指标分析疾病负担变化情况,以及不同性别和年龄段之间的差异。选用Joinpoint回归模型,分析中国归因于高BMI的痴呆症疾病负担变化趋势。结果1990—2019年,中国归因于高BMI的痴呆症疾病负担持续增加,死亡人数增加2.03万例,DALYs增加40.42万人年,死亡率和DALYs率均增加4倍以上。女性疾病负担整体大于男性,但男性疾病负担的增长率高于女性,80岁以上年龄组的疾病负担明显高于其他年龄组。结论关注高BMI的人群,尤其要重视防控肥胖老年群体的痴呆发病风险,采取积极应对措施控制痴呆症的发生。

Objective To understand the changing trend of dementia disease burden attributed to high BMI in China from 1990-2019,and to provide a basis for the development of dementia prevention and control strategies.Methods Using data from the Global Burden of Disease Study 2019(GBD 2019),the changes in disease burden were analyzed using indicators such as deaths,disability adjusted life years(DALYs),years lived with disability(YLDs),years of life lost(YLLs)and their standardized rates.The differences between sexes and age groups were compared.Joinpoint regression model was used to analyze the trend of changes in the disease burden of dementia attributable to high BMI in China.Results From 1990 to 2019,the burden of dementia disease attributed to high BMI continued to increase,with 20300 more deaths,404200 more DALYs,and more than a four-fold increase in both mortality and DALYs rates.The overall burden of disease was greater for women than for men,but the rate of increase in the burden of disease was higher for men than for women.The disease burden in the age group of 80 and over was significantly higher than in other age groups.Conclusion Attention should be paid to people with high BMI,especially for the prevention and control of dementia risk in older age groups with high BMI.Active countermeasures should be taken to control the occurrence of dementia.