武汉市首起猴痘聚集性疫情流行病学调查处置

Epidemiological investigation and management of the firstmonkeypox cluster outbreak in Wuhan

目的描述武汉市首起猴痘聚集性疫情的流行病学特征和调查处置过程,为今后猴痘聚集性疫情防控提供参考依据。方法对病例开展现场流行病学调查,采集病例的咽拭子、肛拭子、疱疹液、血样标本,采样实时荧光定量多聚核苷酸链式反应进行猴痘病毒核酸检测及基因测序。结果2例病例于2023年6月2日在武汉市某酒店发生一次高风险暴露行为。首发病例于6月5日出现米白色丘疹,6月11日于武汉市某三甲医院就诊,其疱疹液样本经中国疾病预防控制中心复核为猴痘病毒核酸阳性。基因测序结果显示,病例感染的猴痘病毒属西非系B.1分支。结论综合流行病学调查和实验室结果,该起猴痘聚集性疫情可能由隐匿性男男性行为传播引起。猴痘在中国同时存在境外输入和本地传播的风险,对猴痘疫情的早发现、早报告和早处置非常必要。

Objective To describe the epidemiological characteristics,investigation and treatment process of the first monkeypox cluster outbreak in Wuhan,and to provide reference for the prevention and control of monkeypox cluster outbreak in the future.Methods Field epidemiological investigation was conducted on the cases,and throat swabs,anal swabs,shingles fluid,whole blood,and serum samples were collected from the cases.Subsequently,real-time fluorescence quantitative polymerase chain reaction was employed for the detection of monkeypox virus nucleic acid and subsequent gene sequencing.Results Two cases had a high-risk exposure behavior in a hotel in Wuhan on June 2,2023.The first case exhibited the emergence of beige papules on June 5 and sought medical treatment at a tertiary hospital in Wuhan on June 11.The Chinese Center for Disease Control and Prevention conducted tests on herpes fluid samples,which yielded positive results for the presence of monkeypox virus nucleic acid.Genetic sequencing analysis revealed that the infecting strain of the monkeypox virus in this case belonged to the West African clade B.1.Conclusion Based on epidemiological investigation and laboratory results,this monkeypox cluster outbreak may be caused by latent men with men sexual transmission.Monkeypox has the risk of both overseas importation and local transmission in our country.It is very necessary to detect,report and deal with monkeypox outbreak early.