纳米材料在椎间盘修复治疗中的研究进展

Advancements in nanomaterials for intervertebral disc repair and treatment summary

椎间盘退变(IVDD)是导致腰腿痛和慢性残疾的一种常见疾病,它涉及椎间盘结构的退化,包括髓核(NP)、纤维环(AF)和软骨终板(CEP)的变化。随着年龄增长,这些部分可能会损伤,导致疼痛和功能障碍。为了治疗IVDD,研究者正在探索使用纳米材料作为新型治疗手段。本综述旨在概述不同类型的纳米材料在IVDD靶向药物治疗和组织修复中的应用。这些纳米材料,如纳米纤维、纳米粒子和纳米水凝胶,可以用来传递药物,促进受损椎间盘的修复和再生。这些方法提供了靶向治疗,减少了不良反应,并有望改善IVDD患者的治疗效果。

Intervertebral disc degeneration(IVDD)is a common disease that leads to back and leg pain and chronic disability.It involves the degeneration of intervertebral disc structures,including changes in the nucleus pulposus(NP),annulus fibrosus(AF),and cartilage endplate(CEP).As age increases,these parts may become damaged,leading to pain and functional impairment.In order to treat IVDD,researchers are exploring the use of nanomaterials as a new therapeutic approach.This review aims to outline the application of different types of nanomaterials in IVDD targeted drug therapy and tissue repair.These nanomaterials,such as nanofibers,nanoparticles,and nanogels,can be used to deliver drugs,promoting the repair and regeneration of damaged intervertebral discs.These methods provide targeted treatment,reduce side effects,and are hoped to improve the treatment outcomes for IVDD patients.