大补阴丸联合生长贴对30例青春早期偏矮女童预测成年身高的影响

The effect of Dabuyin Wan(大补阴丸)combined with growth patches on predicting adult height in 34 young girls with early puberty and short stature

目的观察大补阴丸联合生长贴综合治疗对青春早期偏矮女童性发育进程、骨龄增长及预测成年身高变化的影响。方法选取2021年11月至2022年11月在宁波市江北区中医院中医科门诊就诊的68例乳房处于B2期,骨龄正常或偏大的8~9岁身材偏矮女童,按照随机数字表法分为对照组和治疗组,因受疫情影响未能规律服药或贴敷治疗各脱落4例,最终每组30例。2组均给予饮食、运动、睡眠指导,对照组口服中成药大补阴丸,治疗组在对照组治疗方法的基础上联合生长贴穴位贴敷治疗,2组均连续治疗6个月后统计疗效。结果治疗后,治疗组的身高、生长速度(GV)、身高标准差数值差(△HtSDS)、预测成年身高(△PAH)均较对照组显著升高,2组比较,差异均有统计学意义(P<0.05或P<0.01);2组骨龄增长/年龄增长(△BA/△CA)比较,差异无统计学意义(P>0.05)。治疗前2组的子宫及卵巢容积比较,差异无统计学意义(P>0.05),具有可比性;治疗后2组的子宫及卵巢容积均较同组治疗前显著缩小,差异均有统计学意义(P<0.05),但2组治疗后比较,差异无统计学意义(P>0.05)。治疗前2组的血清类胰岛素生长因子-1(IGF-1)水平比较,差异无统计学意义(P>0.05),具有可比性;治疗后对照组的血清IGF-1水平与同组治疗前比较,差异无统计学意义(P>0.05),而治疗组与同组治疗前及对照组治疗后比较,血清IGF-1水平均显著上升,差异均有统计学意义(P<0.01)。治疗过程中,对照组未见明显不良反应,治疗组出现2例贴敷部位皮肤发红,但不影响治疗。结论大补阴丸联合生长贴治疗青春早期偏矮女童,在减缓性发育及骨龄进展的同时,可以加速身高增长,提高血清IGF-1水平,使预测成年身高增加,且未见明显不良反应,值得临床推广应用。

Objective To observe the clinical efficacy of Dabuyin Wan(大补阴丸)combined with growth patches on the sexual development process,bone age growth,and the impact on predicting adult height changes in short girls in early adolescence.Methods A total of 68 short stature girls aged 8-9 with normal or larger bone age and breast stage B2 were selected from the outpatient department of Jiangbei District Traditional Chinese Medicine Hospital in Ningbo City from November 2021 to November 2022.They were randomly divided into a control group and a treatment group using a random number table method.Due to the impact of the epidemic,4 cases each fell off due to irregular medication or patch treatment,with a total of 30 cases in each group.Both groups were given guidance on diet,exercise and sleep.The control group took traditional Chinese patent medicines and simple preparations Dabuyin Pill.The treatment group was treated with acupoint application of Growth Patch on the basis of the treatment method of the control group.The efficacy of both groups was counted after 6 months of continuous treatment.Results After the treatment,the height,growth rate(GV),△HtSDS,and△PAH of the treatment group were significantly higher than those of the control group.The differences between the two groups were statistically significant(P<0.05 or P<0.01),while there was no statistically significant difference in△BA/△CA between the two groups(P>0.05).The comparison of uterine and ovarian volumes between the two groups before treatment showed no statistically significant difference(P>0.05),indicating comparability.After intervention,the uterine and ovarian volumes of the two groups significantly decreased compared to before intervention,and the differences were statistically significant(P<0.05).However,there was no statistically significant difference between the two groups after treatment(P>0.05).The comparison of serum IGF-1 levels between the two groups before treatment showed no statistically significant difference(P>0.05),indicating comparability.After treatment,there was no statistically significant difference in serum IGF-1 levels between the control group and the same group before treatment(P>0.05),while the treatment group showed a significant increase in serum IGF-1 levels compared to the same group before treatment and the control group after treatment(P<0.01).During the treatment process,there were no significant adverse reactions observed in the control group,while in the treatment group,there were 2 cases of skin redness at the application site,which did not affect the treatment.Conclusion The combination of Dabuyin Wan(大补阴丸)and Growth Patch can intervene in short girls in early adolescence,slow down sexual development and bone age progression,accelerate height growth,increase serum IGF-1 levels,predict adult height increase without significant adverse reactions,and is worthy of clinical promotion and application.