靶向T细胞免疫治疗急性髓性白血病的策略

Strategy of Targeted T Cell Immunotherapy for Acute Myeloid Leukemia

急性髓性白血病(AML)常伴有T细胞免疫功能不全,由于免疫检查点(IC)分子表达上调引起T细胞耗竭是其重要原因之一。利用IC抑制剂治疗AML有一定的临床效果,但患者T细胞耗竭的异质性很大,且还存在其他原因引起的T细胞免疫功能不全,多层面分析区分不同类型的免疫缺陷而采取相应的靶向T细胞免疫治疗才是理想的策略。

T cell dysfunction is a common feature in patients with acute myeloid leukemia(AML).The up-regulation of immune checkpoint(IC)proteins resulting in T cell exhaustion is a key reason for T cell dysfunction.Immunotherapy with IC inhibitors exerts a remarkable effect on AML.However,due to the heterogeneity of T cell exhaustion and other factors that impair T cell function in patients with AML,the optimization of targeted T cell immunotherapy strategy for AML might be based on the multidimensional investigation of immune deficiency with different T cell subtypes.