稀土上转换发光材料的设计及在光动力治疗中的应用研究进展

Research Progress in the Design of Rare-earth Up-conversion LuminescentMaterials and Their Application in Photodynamic Therapy

作为一种新兴的无创治疗方法,光动力治疗在癌症治疗方面具有副作用小、累积毒性小、有效杀伤肿瘤以及精准的靶向治疗而不损伤邻近组织等优势,是理想的癌症治疗方法之一。本文首先简要概括了光动力治疗的机理、基本要素以及细胞作用机制,讨论了稀土上转化发光材料的设计特点以及光动力治疗对上转化发光材料的要求,进一步详述了上转换发光纳米材料、光敏剂以及靶向体的材料结合方式和应用效果,最后综述了光动力治疗和放疗、化疗及光热治疗相结合的协同治疗的进展。

As an emerging non-invasive therapeutic approach, photodynamic therapy is an ideal cancer treatment method due to the low number of side effects, low cumulative toxicity, effective tumor destruction, and precise targeting without damaging adjacent tissues. In this review, we first briefly outline the mechanism, basic elements, and cellular reaction mechanisms of photodynamic therapy. After that, the design features of rare-earth up-conversion luminescent materials and the requirements of photodynamic therapy for up-conversion luminescent materials are discussed. In addition, the material combination methods of up-conversion luminescent nanomaterials, photosensitizers, and targeting substances, as well as the application effects, are summarized. Lastly, the progress of synergistic therapy combining photodynamic therapy with radiotherapy, che- motherapy , and photothermal therapy is reviewed.