儿童造血干细胞回输护理的最佳证据总结

Summary of best evidence for nursing of hematopoietic stem cell reinfusion in children

目的检索并总结儿童造血干细胞回输护理的最佳证据。方法检索BMJ Best Practice、英国国家卫生与临床优化研究所、美国国立指南网、国际指南协作网、苏格兰校际指南网、澳大利亚乔安娜布里格斯研究所循证卫生保健中心数据库、UpToDate、CINAHL、Embase、PubMed、中国知网、万方数据库、维普网等中英文数据库及相关网站中关于儿童造血干细胞回输护理的临床决策、指南、推荐实践、证据总结、系统评价、专家共识等,检索时限为建库至2023年3月。由2名研究者独立进行文献质量评价、确定纳入文献,逐条提取证据内容并对证据进行翻译、整理与汇总。结果共纳入文献9篇,其中临床决策2篇,专家共识2篇,指南4篇,证据总结1篇。从患儿准备、干细胞准备、物品准备、回输中护理、回输后护理、评估与教育6个方面,最终纳入24条证据。结论儿童造血干细胞回输护理的最佳证据总结涉及面广,管理者及临床医护人员应结合具体医疗情境进行证据的应用,以期安全合理地进行造血干细胞回输。

Objective To retrieve and summarize the best evidence for nursing of hematopoietic stem cell reinfusion in children.Methods Clinical decisions,guidelines,recommended practices,evidence summaries,systematic reviews,and expert consensuses on nursing of hematopoietic stem cell reinfusion in children were searched in Chinese and English databases as well as related websites such as British Medical Journal(BMJ)Best Practice,National Institute for Health and Clinical Excellence,National Guideline Clearinghouse,Guidelines International Network,Scottish Intercollegiate Guidelines Network,Joanna Briggs Institute Evidence-Based Health Care Center Database,UpToDate,CINAHL,Embase,PubMed,China National Knowledge Infrastructure,WanFang Data,and VIP.The search period was from database establishment to March 2023.Two researchers independently conducted literature quality evaluation,identified the included literature,extracted evidence item by item,and translated,organized and summarized the evidence.Results A total of nine articles were included,including two clinical decisions,two expert consensuses,four guidelines,and one evidence summary.24 pieces of evidence were summarized from six aspects,consisting of child preparation,stem cell preparation,item preparation,nursing during reinfusion,nursing after reinfusion,and evaluation and education.Conclusions The best evidence for nursing of hematopoietic stem cell reinfusion in children involves a wide range of aspects.Managers,clinical medical and nursing staff should apply evidence based on specific medical situations in order to safely and reasonably perform hematopoietic stem cell reinfusion.