无功能性胰腺神经内分泌肿瘤临床诊断与手术治疗的研究进展

Clinical diagnosis and surgical treatment of nonfunctional pancreatic neuroendocrine neoplasms:a review of research progress

胰腺神经内分泌肿瘤(pNEN)是一种罕见的异质性肿瘤,具有多种恶性潜能。随着横断面成像的广泛应用,无症状的无功能性胰腺神经内分泌肿瘤(NF-pNEN)被诊断的频率逐年升高,但仍存在临床确诊难度大,手术治疗不及时等诸多方面的不足。加深对NF-pNEN的认识有助于提高临床诊断率,进而采取及时有效的治疗。笔者就NF-pNEN在临床诊断与外科治疗中存在的争议问题进行综述,以期为临床提供参考。

Pancreatic neuroendocrine neoplasms(pNENs)are rare heterogeneous tumors with various malignant potentials.With the widespread application of cross-sectional imaging,the frequency of diagnosis of asymptomatic non-functional pancreatic neuroendocrine neoplasms(NF-pNENs)is increasing annually.However,there are still significant challenges in clinical diagnosis,delayed surgical treatment,and other aspects.Deepening the understanding of NF-pNENs can help improve the clinical diagnostic rate and subsequently implement timely and effective treatment.In this review,the authors discuss the controversial issues in the clinical diagnosis and surgical treatment of NF-pNENs,aiming to provide reference for clinical practice.