胰十二指肠切除术后高淀粉酶血症的研究进展

Postoperative hyperamylasemia following pancreaticoduodenectomy:a research progress review

胰十二指肠切除术(PD)术后并发症发生率高达40%,故对其并发症的早期预测及处理是有必要的。PD术后高淀粉酶血症(POH)被认为是术后早期并发症发生率及严重程度的预测因子,但因对血清淀粉酶活性升高的机制不明确,其意义和含义近些年以不同的方式被解释。在此,笔者就POH概念的提出与发展历程、原因及影响、与术后急性胰腺炎及术后胰瘘之间的关系,以及防治措施等加以综述。

Postoperative complications after pancreaticoduodenectomy(PD) occur at a high rate of up to 40%,thus early prediction and management of its complications are necessary.Postoperative hyperamylasemia(POH) following PD is considered a predictor of the occurrence rate and severity of early postoperative complications,but due to the unclear mechanism of elevated serum amylase activity,its significance and implications have been interpreted in various ways in recent years.Here,the authors review the concept and development history of POH,its causes and impacts,its relationship with postpancreatectomy acute pancreatitis and postoperative pancreatic fistula,as well as prevention and treatment measures.