胶原蛋白肽对人牙周膜成纤维细胞损伤的保护作用

Protective Effect of Collagen Peptides on Human Gingival Fibroblasts Injury

文章以脂多糖(LPS)为致病因子,通过刺激人牙周膜成纤维细胞(h PDLFs)建立模型,研究胶原蛋白肽(CP)对口腔的保护作用及其可能机制。结果表明,100 mg/mL以上质量浓度的CP能有效降低LPS对hPLDFs的毒性,显著提高h PLDFs的增殖能力,同时也能有效降低TLR4和NF-κB的表达量,对炎症因子的分泌产生明显的影响。作用机理可能是,CP作为一种信号分子作用于TLR4,通过抑制TLR4和NF-κB的表达来抑制LPS引起的炎症反应,从而促进hPDLFs增殖。

The paper studied the protective effect of collagen peptides on human periodontal ligament fibroblasts(hPDLFs)induced by lipopolysaccharide and its possible mechanism.The results showed that collagen peptides above 100 mg/mL could effectively reduce the toxicity of lipopolysaccharide,and significantly reduce IL-8 and TNF-αproduced by lipopolysaccharide,suggesting that collagen peptides can provide effective and safe solutions to oral cavity repair.