基于“肺与大肠相表里”讨论调节肠道菌群在儿童肺炎中的应用

Discussion on the application of regulating intestinal microflora in children with pneumonia based on the relationship between lung and large intestine

肺炎是儿童常见疾病,是导致5岁以下儿童死亡的主要原因之一,而细菌是发展中国家儿童肺炎中最常见的病原体,临床上治疗药物以抗生素为主,但全球细菌耐药形势严峻,已成为威胁人类健康的重要问题。中医认为,“肺与大肠相表里”,强调“肺肠同治”,现代医学提出“肺-肠轴”,发现肠道菌群的变化影响肺系疾病的发生、发展及转归,并提出通过干预菌群治疗肺系疾病。本文旨在讨论益生菌在儿童肺炎中肺肠同治作用,为临床治疗儿童肺炎提供新思路。

Pneumonia is a common disease in children and one of the main causes of death in children under 5 years old.Bacteria are the most common pathogen in pneumonia among children in developing countries,and antibiotics are the main treatment drugs in clinical practice.However,the global situation of bacterial resistance is severe,which has become a great threat to human health.In traditional Chinese medicine it is believed that"the lungs and large intestine are related externally and internally,"emphasizing the principle of"treating the lungs and intestines together."Modern medicine proposes the"lung gut axis,"which reveals that changes in intestinal microbiota affect the occurrence,development,and prognosis of pulmonary diseases.It also proposes the method of treating pulmonary diseases by intervening in the microbiota.This article aims to demonstrate the role of probiotics in the treatment of lung and intestine simultaneously in children with pneumonia,providing new ideas for clinical treatment of pediatric pneumonia.