脑小血管病血液生物标志物的研究进展

Research advances in blood biomarkers for cerebral small vessel disease

脑小血管疾病(CSVD)是一组由各种病因引起的关于脑血管系统病变,从而导致一系列临床、影像学、病理表现的动态性血管性疾病。人类预期寿命的普遍增长,高患病率、高复发率的特征使CSVD受到普遍关注。随着影像学、神经病理生理学等研究发展,CSVD患者的发病机制和诊断治疗取得些许进展。目前,研究人员发现通过对CSVD血液生物标志物的研究可能有助于提高疾病早期诊断、早期干预及改善预后。并且血液生物标志物的易取性及简便性使其在临床上能具有更广泛的应用前景。本文就CSVD相关血液生物标志物的研究进展进行综述。

Cerebral small vessel disease(CSVD)is a dynamic vascular disease of the cerebrovascular system caused by various etiologies,resulting in a series of clinical,imaging,and pathological manifestations.With the increase in human life expectancy,CSVD has attracted much attention due to its high incidence and recurrence rates.With the research advances in imaging and neurophysiology,some progress has been made in the pathogenesis,diagnosis,and treatment of CSVD.Currently,researchers have found that the study of blood biomarkers for CSVD may help to achieve early diagnosis and intervention and improve prognosis.In addition,the accessibility,simplicity,and convenience of blood biomarkers make them promising for wide clinical application.This article reviews the research advances in blood biomarkers for CSVD.