摘要
为探究实验室制备β-烟酰胺单核苷酸(NMN)霜的生物功效,借助小鼠光老化模型和自然衰老模型对NMN霜的抗衰老作用及生物安全性进行了评估。结果显示,NMN霜可以通过提高皮肤及血液中抗衰老因子(NAD+和SIRT3)、上调血液中过氧化氢酶(CAT)和超氧化物歧化酶(SOD)的活力及促进皮肤胶原纤维生成达到抗衰老效果;NMN霜治疗组小鼠的血液指标及五脏H&E染色结果相比对照组均无异常,提示NMN霜的生物安全性较高。
In order to investigate the biological efficacy of the lab-madeβ-nicotinamide mononucleotide(NMN)cream,the anti-aging effect and biosafety of the cream were studied by means of mouse photoaging model and natural aging model.The results showed that NMN cream could improve the expression of anti-aging factors(NAD+and SIRT3)in skin and blood samples,up-regulate the activities of catalase(CAT)and superoxide dismutase(SOD)in blood,promote the formation of skin collagen fibers to achieve the anti-aging effect.In comparation with the control group,no significant difference was noticed in the blood indexes and H&E staining results of the five organs in the NMN cream treatment group,suggesting a highly biological safety of NMN cream.
作者
韦杏芳
张泽奇
史雨馨
罗嘉
袁燕燕
林鹏任
王淑贤
查梦蕾
杨平顺
WEI Xingfang;ZHANG Zeqi;SHI Yuxin;LUO Jia;YUAN Yanyan;LIN Pengren;WANG Shuxian;ZHA Menglei;YANG Pingshun(Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen 518055,Guangdong,China;Shenzhen Rongda Biotechnology Co.,Ltd.,Shenzhen 518000,Guangdong,China)
出处
《香料香精化妆品》
CAS
2024年第2期55-61,164,共8页
Flavour Fragrance Cosmetics
基金
南科大生医工系-容大生物康美联合实验室(编号K2138Z119)。
