慢性心力衰竭相关性肌少症的研究进展

Progress in study of sarcopenia associated with chronic heart failure

慢性心力衰竭(chronic heartfailure,CHF)是心血管疾病的终末表现和最主要死亡原因,是21世纪心血管领域的两大挑战之一。肌少症的发生发展与年龄、合并慢性疾病、癌症等有关,且研究表明,肌少症与CHF之间存在相互作用的关系。随着人口老龄化的加剧,CHF合并肌少症所带来的经济、家庭负担将进一步加重。CHF相关性肌少症可能与营养不良、肌血流量降低、炎症、胰岛素抵抗、激素分泌失调、自噬和细胞凋亡等相关,目前对于该疾病的治疗尚未找到靶向治疗,主要通过干预生活方式、改变饮食习惯、药物和激素等措施治疗。本文对CHF合并肌少症的评估及早期筛查、发病机制、治疗及干预措施等方面进行综述,为临床医生对该病的预防和治疗提供思路。

Chronic heart failure(CHF)is the end stage of cardiovascular diseases and the most important cause of death.It is one of the two major challenges in cardiovascular field in the 21st century.The occurrence and development of sarcopenia are related to the age,chronic diseases and cancer;and studies have shown that sarcopenia and CHF have an interactive relationship.With the aging of the population,the economic and family burden caused by CHF with sarcopenia will further increase.CHF-related sarcopenia may be associated with malnutrition,decreased muscle blood flow,inflammation,insulin resistance,hormone dysfunction,autophagy,and apoptosis.Currently,there is no targeted treatment for this disease.The main treatment methods include lifestyle interventions,dietary changes,drugs,hormones and other measures.This article summarizes the evaluation and early screening,pathogenesis,treatment and intervention measures of CHF with sarcopenia,providing ideas for the prevention and treatment.