放射性核素对双能X射线骨密度仪检测骨密度的影响研究

Study on the influence of radionuclides in measuring bone mineral density by using DXA

目的:研究核医学检查和治疗中常用放射性核素对双能X射线骨密度仪(DXA)检测骨密度(BMD)的影响。方法:对DXA设备专用质量保证(QA)模块和脊椎模体均进行常规扫描,在QA模块旁及脊椎模体的水槽中分别加入常用放射性核素锝99m(^(99)Tc^(m))-亚甲基二膦酸盐(^(99)Tc^(m)-MDP)、氟18(^(18)F)-氟代脱氧葡萄糖(^(18)F-FDG)和碘[^(131)I]化钠(Na^(131)I)后扫描,对检测所得高、中、低BMD值、身体成分百分含量值、第1、2、3、4节腰椎(L_(1)、L_(2)、L_(3)、L_(4))及4节腰椎平均(L_(1)~L_(4))BMD值、T值进行对比分析。结果:在QA模块旁分别放置^(99)Tc^(m)-MDP、^(18)F-FDG、Na^(131)I后的扫描与QA模块的常规扫描所得高、中、低BMD值及身体成分百分含量值相比,差异均无统计学意义(F_(BMD值)=1.621、0.259、0.099,F_(身体成分百分含量值)=0.367、0.151、0.635;P>0.05);向脊椎模体的水槽中分别注入放射性核素^(99)Tc^(m)-MDP、^(18)F-FDG、Na^(131)I后的扫描和脊椎模体的常规扫描所得L_(1)、L_(2)、L_(3)、L_(4)及L_(1)~L_(4)的BMD值及T值相比,差异均无统计学意义(F_(BMD值)=0.435、0.529、0.507、0.489、0.516,F_(T值)=0.634、1.585、0.961、0.777、0.801;P>0.05)。结论:核医学检查和治疗中常用放射性核素^(99)Tc^(m)-MDP、^(18)F-FDG、Na^(131)I对DXA检测BMD无影响。

Objective:To study the influence of common radionuclides in measuring bone mineral density(BMD)by using dual-energy X-ray absorptiometry(DXA)in medical examination and therapy.Methods:Both the special quality assurance(QA)module of DXA equipment and the spine phantom were scanned by routine scan.The scan was performed after the common radionuclides included ^(99)Tc^(m)-methylene diphosphonate(^(99)Tc^(m)-MDP),^(18)F-fluorodeoxyglucose(^(18)F-FDG)and sodium iodide(Na^(131)I)were respectively added into sink beside of QA module and spine phantom.The high,middle and low BMD values,the percentage value of body composition,the BMD values of the 1st,2nd,3rd and 4th lumbar spine(L_(1),L_(2),L_(3),L_(4)),and the average BMD value of 4-segment lumbar spines(L_(1)-L_(4)),T value,which were obtained from measure,were compared and analyzed.Results:There were no significant differences in high,middle and low BMD values and the percentage of body composition between the scan after ^(99)Tc^(m)-MDP,^(18)F-FDG and Na^(131)I were respectively placed next to QA module and the routine scan of QA module(F_(BMD)=1.621,0.259,0.099,F_(Body Composition)=0.367,0.151,0.635,P>0.05).There were no significant differences in BMD values and T values of L_(1),L_(2),L_(3) and L_(4),and the L_(1)-L_(4) between the scan after ^(99)Tc^(m)-MDP,^(18)F-FDG and Na^(131)I were respectively injected in the sink of spine phantom and the routine scan of spine phantom(F_(BMD)=0.435,0.529,0.507,0.489,0.516,F_(T)=0.634,1.585,0.961,0.777,0.801,P>0.05).Conclusion:The common radionuclides ^(99)Tc^(m)-MDP,^(18)F-FDG and Na^(131)I do not affect the DXA measure for BMD in nuclear medicine examination and therapy.