围术期不同吸入氧浓度与术后肺部并发症的研究进展

Research progress on the correlation of perioperative inhaled oxygen at varying concentrations with postoperative pulmonary complications

围术期吸氧治疗是一种常规的呼吸支持措施,不同的吸入氧浓度(FiO_(2))对患者的影响不同,吸入高浓度氧气可以减轻术后恶心呕吐和预防手术部位感染的观念已逐渐改变,氧气作为一种强氧化剂,其引发的氧化应激反应可对肺部造成氧化损伤,进而增加术后肺部并发症(postoperative pulmonary complications,PPC)的发生率。PPC能显著增加术后早期死亡率、ICU入住率和住院时间。围术期机械通气时不同FiO_(2)的使用与PPC的发生密切相关。通过回顾近期研究,探讨不同FiO_(2)对PPC的影响,为临床医生提供关于围术期氧气管理的科学依据,以通过更加优化的围术期氧气管理策略,减少PPC风险并提高患者术后恢复质量。

During the perioperative period,oxygen therapy is a routine respiratory support measure.However,the impact of the fraction of inspired oxygen(FiO_(2))at the varying concentrations differs a lot.The conventional theory of inhaling high concentrations of oxygen in reducing postoperative nausea and vomiting and preventing surgical site infections has gradually evolved.Oxygen is a potent oxidizing agent to trigger oxidative stress responses and oxidative damage in the lungs,thereby increasing the incidence of postoperative pulmonary complication(PPC).PPC can significantly increase early postoperative mortality,ICU admissions,and length of stay.Current research demonstrated a close correlation of the use of FiO_(2) at varying concentrations during perioperative mechanical ventilation with the occurrence of PPC.This review,by revisiting recent studies,explored the effects of FiO_(2) at varying concentrations on PPC,offering scientific evidences for perioperative oxygen management.The aim of this review was to decrease the risk of PPC and enhance the quality of postoperative recovery through more optimized perioperative oxygen management strategies.