肠道菌群及耐药基因组与抗生素之间关系的研究进展

Relation of intestinal flora and drug resistance genome with antibiotics:a research progress

肠道菌群携带的基因被认为是人类的“第二基因组”,肠道菌群也是抗生素耐药基因(ARG)的储存库。肠道菌群组成和功能的紊乱与多种疾病有关。而抗生素的使用打破了肠道菌群原有的稳态,加剧了ARG的传播和扩散,增加了特异性ARG的丰度,对临床治疗造成不良影响。本文就肠道菌群及耐药基因组与抗生素之间的关系做一综述,并对未来研究方向进行展望,以期为肠道耐药基因组的研究提供新思路,同时为临床上合理使用抗生素提供理论依据。

Genes carried by intestinal flora are considered as“the second genome”of humans,and intestinal flora is also reservoir of antibiotic resistance gene(ARG).Disturbance in composition and function of intestinal flora is related to multiple diseases.However,the use of antibiotics disrupts the original homeostasis of intestinal flora,intensifies spread and diffusion of ARG,increases abundance of specific ARG,and exerts adverse effects on clinical treatment.In this review,the relation of intestinal flora and drug resistance genome with antibiotics is summarized,and future research directions are prospected,aiming at providing new ideas for the research of intestinal drug resistance genome and theoretical basis for the rational use of antibiotics in clinics at the same time.