中性粒细胞胞外诱捕网在免疫相关性疾病中的作用及相关药物的研究进展

The Role of Neutrophil Extracellular Traps in Immune-related Diseases and the Research Progress of Related Drugs

中性粒细胞胞外诱捕网(NET)的形成是最近发现的中性粒细胞发挥机体保护功能的一种方式。然而,过量的NET被机体识别为自身抗原,参与多种免疫相关性疾病的发生和发展进程,最终导致机体损伤。基于最新的文献报道,综述了NET的形成机制及其在系统性红斑狼疮和类风湿关节炎等免疫相关疾病发生和发展中的重要作用。此外,针对现有调控靶点和相关药物进行总结,旨在为NET抑制剂的临床应用和深入研究提供参考。

The formation of neutrophil extracellular traps(NETs)is a recently discovered way for neutrophils to exert their protective function in the body.However,excessive NETs are recognized by the body as autoantigens,which can participate in the onset and progression of immune-related diseases,ultimately resulting in bodily injury.Based on the recent literature,this article reviews the mechanisms for the formation of NETs and their significant roles in the onset and progression of immune-related diseases,including systemic lupus erythematosus and rheumatoid arthritis.Futhermore,the article summarizes existing regulatory targets and related drugs,aiming to provide references for clinical application and further research of NET inhibitors.