两性离子-阴离子双交联P(AAm-co-AAc-co-SBMA-co-AMPS)/Fe^(3+)水凝胶的摩擦学性能研究

Tribological properties of zwitterionic-anionic dual-crosslinked P(AAm-co-AAc-co-SBMA-co-AMPS)/Fe^(3+)hydrogel

水凝胶是一种理想的软骨修复材料,但目前很难有人工材料能实现软骨的超低摩擦因数。使用两性离子单体[2-(甲基丙烯酰氧基)乙基]二甲基-(3-磺丙基)(SBMA)和阴离子单体2-丙烯酰氨基-2-甲基丙磺酸(AMPS)合成一种两性离子-阴离子双交联P(AAm-co-AAc-co-SBMA-co-AMPS)/Fe^(3+)水凝胶。在水和PBS中进行摩擦学测试,以评估两性离子和阴离子基团对摩擦因数(CoF)的影响。结果表明:SBMA和AMPS引入的物理交联点可以提高水凝胶的抗压强度,在水中实现了较低CoF(0.04);此外,在PBS中观察到CoF进一步降低至0.015,CoF的降低是由于水凝胶在PBS中浸泡产生的高度水合上层所造成的。

Hydrogel is an ideal material for cartilage repair,but it is difficult for artificial materials to achieve ultra-low friction coefficient of cartilage at present.The amphoteric ion anionic double crosslinked P(AAmco-AAc-co-SBMA-co-AMPS)/Fe^(3+)hydrogel was synthesized by using the amphoteric monomer[2-(methacryloxy)ethyl]dimethyl-(3-sulfopropyl)(SBMA)and the anionic monomer 2-acrylamido-2-methylpropane sulfonic acid(AMPS).The frictional tests were conducted in water and PBS to evaluate the effects of zwitterionic and anionic groups on the coefficient of friction(CoF).The results show that the physical crosslinking point introduced by SBMA and AMPS can improve the compressive strength of hydrogel,and achieve a low CoF(0.04)in water,In addition,it is observed that CoF further decreases to 0.015 in PBS,and the decrease of CoF is caused by the highly hydrated upper layer of hydrogel produced during PBS soaking.