甲状腺癌采取细针穿刺细胞学检查联合braf^(V600E)基因检测的诊断价值

Diagnostic Value of Fine-Needle Aspiration Cytology Combined with BRAF~(V600E) Gene Testing in Thyroid Cancer

目的 探讨甲状腺癌采取细针穿刺细胞学检查联合braf^(V600E)基因检测的诊断价值。方法 选取河南省直第三人民医院2021年1月至2022年12月收治的81例甲状腺结节疑似甲状腺癌患者,均行细针穿刺细胞学检查、braf^(V600E)基因检测。以术后病理为金标准,比较细针穿刺细胞学检查、braf^(V600E)基因检测及其联合诊断的价值。结果 81例甲状腺结节患者中,甲状腺乳头状癌36例,良性结节45例。联合检查的阳性、阴性检出情况均高于braf^(V600E)基因检测、细针穿刺细胞学单项检查,差异有统计学意义(P <0.05)。联合检查的阳性预测值、阴性预测值均高于braf^(V600E)基因检测、细针穿刺细胞学检查单项检查,差异有统计学意义(P <0.05)。细针穿刺细胞学检查、braf^(V600E)基因检测及联合检查对甲状腺癌诊断的灵敏度分别为58.33%、69.44%、97.22%,特异度分别为91.11%、91.11%、100.00%,准确度分别为81.48%、76.54%、98.77%,联合诊断甲状腺癌的灵敏度、准确度均高于单项检查,差异有统计学意义(P <0.05)。结论 甲状腺癌采用细针穿刺细胞学检查联合braf^(V600E)基因检测的诊断价值较高,值得借鉴。

Objective To explore the diagnostic value of fine-needle aspiration cytology(FNAC) combined with braf~(V600E) gene testing in thyroid cancer.Methods A total of 81 patients with suspected thyroid cancer who were admitted to the Third People's Hospital of Henan Province from January 2021 to December 2022 were selected.All patients underwent FNAC and braf~(V600E) gene testing.Postoperative pathology served as the gold standard for comparison of the diagnostic value of FNAC,braf~(V600E) gene testing,and their combination.Results Among the 81 patients with thyroid nodules,there were 36 cases of papillary thyroid carcinoma and 45 cases of benign nodules.The detection rates of positive and negative results in the combined examination were higher than those of braf~(V600E) gene testing and FNAC alone,with statistically significant differences(P < 0.05).The positive predictive value and negative predictive value of the combined examination were higher than those of braf~(V600E) gene testing and FNAC alone,with statistically significant differences(P < 0.05).The sensitivity of FNAC,braf~(V600E) gene testing,and combined examination for diagnosing thyroid cancer were 58.33%,69.44%,and 97.22%,respectively.The specificity were 91.11%,91.11%,and 100.00%,respectively.The accuracy rates were 81.48%,76.54%,and 98.77%,respectively.The sensitivity and accuracy of the combined examination for diagnosing thyroid cancer were higher than those of single tests,with statistically significant differences(P < 0.05).Conclusion The diagnostic value of FNAC combined with braf~(V600E) gene testing in thyroid cancer is high and worthy of reference.