非布司他片治疗痛风伴高尿酸血症的效果

Clinical effects of Febuxostat tablets in the treatment of gout with hyperuricemia

目的 研究与分析不同治疗方式对痛风伴高尿酸血症患者的影响。方法 筛选2021年3月至2023年3月期间在焦作市人民医院就诊的92例痛风伴高尿酸血症患者进行研究。以随机数法分为两组,每组46例。其中参照组以别嘌呤醇治疗,治疗组以非布司他片治疗,对比两组治疗效果,炎性因子与尿酸水平,不良反应,生活质量。结果 治疗组治疗有效率高于参照组,差异有统计学意义(P <0.05);治疗前两组炎性因子与尿酸水平对比,差异无统计学意义(P> 0.05),两组治疗后3个月、6个月肿瘤坏死因子-α(TNF-α)、可溶性细胞间黏附分子-1(sICAM-1)、尿酸(UA)水平均较治疗前降低,且同时段治疗组低于参照组,差异有统计学意义(P <0.05);治疗组不良反应发生率低于参照组,差异有统计学意义(P<0.05);两组治疗后6个月生活质量评分高于治疗前,且治疗组高于参照组,差异有统计学意义(P<0.05)。结论 非布司他片能显著改善痛风合并高尿酸血症症状及UA、sICAM-1、TNF-α水平,临床疗效确切,并且安全性高,可提高患者生活质量。

Objective To study and analyze the effects of different treatment methods on patients with gout accompanied by hyperuricemia.Methods Ninety-two patients with gout accompanied by hyperuricemia who visited Jiaozuo People's Hospital from March 2021 to March 2023 were selected for the study.They were randomly divided into two groups,with 46cases in each group.The reference group was treated with allopurinol,while the treatment group was treated with flurbiprofen axetil.The treatment effects,levels of inflammatory factors and uric acid,adverse reactions,and quality of life were compared between the two groups.Results The effective rate of treatment in the treatment group was higher than that in the reference group,with statistical significance(P < 0.05).There was no significant difference in inflammatory factors and uric acid levels between the two groups before treatment(P > 0.05).After 3 and 6 months of treatment,tumor necrosis factor-alpha(TNF-α),soluble intercellular adhesion molecule-1(sICAM-1),and uric acid(UA) levels decreased in both groups compared to before treatment,and the levels in the treatment group were lower than those in the reference group during the same period,with statistical significance(P<0.05).The incidence of adverse reactions in the treatment group was lower than that in the reference group,with statistical significance(P<0.05).The quality of life scores in both groups were higher after 6 months of treatment compared to before treatment,and the scores in the treatment group were higher than those in the reference group,with statistical significance(P < 0.05).Conclusion Flurbiprofen axetil can significantly improve the symptoms of gout accompanied by hyperuricemia and levels of UA,sICAM-1,and TNF-α,showing definite clinical efficacy and high safety,thereby improving the quality of life of patients.