氟比洛芬酯对行根治性胃切除的患者围术期体温及寒颤的影响

Effect of Flurbiprofen Axetil on Perioperative Body Temperature and Chills in Patients Undergoing Radical Gastrectomy

目的 探讨氟比洛芬酯对行根治性胃切除的患者围术期体温及寒颤的影响。方法 将2020年1月至2021年12月送入商丘仁和中医院院接受根治性胃切除手术治疗的120例患者作为研究对象,依据随机数表法分为对照组60例,观察组60例。在干预方案的实际过程中,对照组剔除5人。观察组患者剔除4人。最终完成本次研究的,对照组55人,观察组56人。麻醉诱导后对照组给予0.9%生理盐水10 mL进行静脉输注,观察组给予氟比洛芬酯100 mg进行静脉输注。对比两组患者的麻醉药物用量及手术相关用时,患者入室时(T1),进入恢复室时(T2),出恢复室时(T3)的平均动脉压、心率、耳膜温度,对比两组患者在恢复室期间的寒颤发生情况及患者拔管后0.5 h及1 h的疼痛严重程度[视觉模拟评分法(VAS)],对比两组拔管后1 h内的不良反应发生情况。结果 两组患者的舒芬太尼使用量、瑞芬太尼使用量、麻醉持续时间、手术持续时间、术后拔管时间差异均无统计学意义(P> 0.05)。两组患者T1、T2、T3的平均动脉压,心率,耳膜温度差异均无统计学意义(P> 0.05)。观察组在恢复室期间的寒颤发生率低于对照组,观察组在恢复室期间的寒颤发生分级低于对照组,差异具有统计学意义(P <0.05)。两组寒颤持续时间差异无统计学意义(P> 0.05)。观察组患者拔管后0.5 h及1 h疼痛严重程度均低于对照组,差异具有统计学意义(P <0.05)。两组拔管后1 h的恶心、呕吐发生率差异无统计学意义(P> 0.05)。结论 行根治性胃切除的患者个体中,在麻醉诱导后给予氟比洛芬酯100 mg进行静脉输注,可以明显的降低手术后寒颤的比例以及严重程度,同时可降低术后的疼痛程度,且用药方法不会对循环系统构成影响,不会额外增加不良反应。

Objective This study aimed to investigate the effects of flurbiprofen axetil on perioperative body temperature and chills in patients undergoing radical gastrectomy.Methods A total of 120 patients undergoing radical gastrectomy surgery from January 2020 to December 2021 were selected.They were randomly divided into two groups:a control group(n=55)and an observation group(n=56).After anesthesia induction,the control group received 10 mL of 0.9% physiological saline intravenously,while the observation group received 100 mg of flurbiprofen ester intravenously.Various parameters,including anesthetic drug dosage,surgery-related time,arterial pressure,heart rate,eardrum temperature,incidence and severity of chills,pain severity[visual analogue scale,(VAS)],and adverse reactions were compared between the two groups.Results There were no significant differences in sufentanil consumption,remifentanil consumption,anesthesia time,operation time,or postoperative extubation time between the two groups(P > 0.05).Additionally,there were no significant differences in mean arterial pressure,heart rate,or eardrum temperature at T1,T2,and T3 time points between the two groups(P > 0.05).The incidence and severity of chills in the recovery room were lower in the observation group than in the control group,with statistically significant differences(P < 0.05).However,there was no significant difference in the duration of chills between the two groups(P > 0.05).Pain severity in the observation group was significantly lower than in the control group at 0.5 and 1.2 hours after extubation(P < 0.05).There was no significant difference in the incidence of nausea and vomiting between the two groups at 1 hour after extubation(P > 0.05).Conclusion Intravenous infusion of 100 mg flurbiprofen axetil after anesthesia induction in patients undergoing radical gastrectomy can significantly reduce the incidence and severity of postoperative chills and alleviate postoperative pain without adverse effects on the circulatory system or additional adverse reactions.