氨氯地平阿托伐他汀钙片治疗高血压合并冠心病患者的疗效观察

Observation on the Therapeutic Effect of Amlodipine Atorvastatin Calcium Tablets on Patients with Hypertension and Coronary Heart Disease

目的 探讨高血压合并冠心病患者使用复合制剂“氨氯地平阿托伐他汀钙片”的实际治疗效果。方法 将2021年5月至2022年12月收治的86例高血压合并冠心病患者纳入为研究对象,按照随机数表法分为对照组和研究组(单数者入对照组、双数者入研究组),各43例。对照组仅使用氨氯地平治疗;研究组则使用氨氯地平阿托伐他汀钙片治疗。对比治疗有效率,治疗前后疗效相关指标[血压水平、心功能指标、明尼苏达心功能不全生命质量量表评分(MLHFQ)]及不良反应。结果 研究组治疗有效率较对照组更高,差异有统计学意义(P <0.05);治疗后研究组血压较对照组更低,差异有统计学意义(P <0.05);治疗后研究组心输出量、左室射血分数、每搏输出量较对照组更高,左室收缩末期、舒张末期内径较对照组更低,差异有统计学意义(P <0.05);治疗后研究组MLHFQ评分较对照组更低,差异有统计学意义(P <0.05);对照组、研究组用药期间不良反应发生率对比差异无统计学意义(P> 0.05)。结论 高血压并冠心病使用复合制剂“氨氯地平阿托伐他汀钙片”治疗的疗效确切,可同时发挥改善心功能、控制血压的双重治疗效果,值得应用。

Objective To explore the actual therapeutic effect of the compound preparation "Amlodipine Atorvastatin Calcium Tablets" on patients with hypertension and coronary heart disease.Methods A total of 86 patients with hypertension complicated with coronary heart disease from May 2021 to December 2022 were included as the study subjects.They were randomly divided into a control group and a study group(odd numbered individuals were included in the control group,and even numbered individuals were included in the study group) using a random number table method,with 43 cases in each group.The control group was only treated with amlodipine;The research group used amlodipine atorvastatin calcium tablets for treatment.Compare the total effective rate of treatment,relevant indicators of efficacy before and after treatment [blood pressure level,cardiac function indicators,Minnesota Living with Heart Failure Questionnaire(MLHFQ)],and adverse reactions.Results The total effective rate of the study group was higher than that of the control group,and the difference was statistically significant(P < 0.05).After treatment,the blood pressure in the study group was lower than that in the control group,and the difference was statistically significant(P < 0.05);After treatment,the study group had higher cardiac output,left ventricular ejection fraction,and stroke output than the control group,while the left ventricular end systolic and end diastolic diameter was lower than the control group,with statistically significant differences(P < 0.05);After treatment,the MLHFQ score of the study group was lower than that of the control group(P < 0.05);There was no significant difference in the incidence of adverse reactions during medication between the control group and the study group(P > 0.05).Conclusion The use of a composite formulation of amlodipine atorvastatin calcium tablets for the treatment of hypertension and coronary heart disease has a definite therapeutic effect,and can simultaneously improve heart function and control blood pressure,making it worthy of application.