拉贝洛尔联合硫酸镁治疗妊娠期高血压疾病的效果观察

The Observations of Labetalol with Magnesium Sulfate in the Treatment of Hypertensive Disorder Complicating Pregnancy

目的 探究拉贝洛尔联合硫酸镁在妊娠期高血压疾病中的治疗效果。方法 将河南科技大学附属许昌市中心医院2022年6月至2023年10月收治的86例妊娠期高血压患者根据随机数字表法分为对照组(43例,硫酸镁治疗)与试验组(43例,拉贝洛尔联合硫酸镁治疗),对比两组治疗情况。结果 治疗后,两组血压水平与24 h尿蛋白定量均下降,且试验组较对照组低,差异均有统计学意义(P <0.05)。试验组治疗有效率(97.67%)高于对照组(83.72%),差异具有统计学意义(P <0.05)。试验组产妇不良结局发生率(2.32%)、新生儿不良结局发生率(0)低于对照组(13.95%、9.30%),差异均有统计学意义(P <0.05)。两组患者不良反应发生率对比,差异无统计学意义(P> 0.05)。结论 在妊娠期高血压疾病患者中联合拉贝洛尔与硫酸镁治疗,可改善其血压水平与24 h尿蛋白定量,提升治疗有效率,降低不良结局发生率,安全可靠。

Objective To explore the therapeutic effect of Labetalol combined with Magnesium Sulfate in the treatment of hypertension during pregnancy.Methods 86 patients with hypertension during pregnancy who were admitted to the Central Hospital of Xuchang,affiliated with Henan University of Science and Technology,from June 2022 to October 2023 were selected as the research subjects.They were divided into a control group(43 cases,treated with Magnesium Sulfate) and an experimental group(43 cases,treated with Labetalol combined with Magnesium Sulfate) according to the random number table method,and the treatment conditions of the two groups were compared.Results After treatment,the blood pressure levels and 24-hour urinary protein quantification of both groups decreased,and the experimental group was lower than the control group,with statistically significant differences(P < 0.05).The effective rate of treatment in the experimental group(97.67%) was higher than that in the control group(83.72%),with a statistically significant difference(P < 0.05).The incidence of adverse outcomes in mothers and newborns in the experimental group(2.32%,0) was lower than that in the control group(13.95%,9.30%),with statistically significant differences(P < 0.05).The incidence of adverse reactions in patients in both groups was compared,and the difference was not statistically significant(P > 0.05).Conclusion The combined treatment of Labetalol and Magnesium Sulfate in patients with hypertension during pregnancy can improve their blood pressure levels and 24-hour urinary protein quantification,increase the effective rate of treatment,reduce the incidence of adverse outcomes,and is safe and reliable.