血液灌流联合血液透析治疗尿毒症患者的临床分析

Clinical Analysis of Hemoperfusion Combined with Hemodialysis in the Treatment of Uremic Patients

目的 探究在尿毒症患者中采用血液灌流联合血液透析治疗的疗效。方法 选取2020年3月—2023年3月东营市东营区人民医院收治的50例尿毒症患者为研究对象,按随机数表法分为研究组、对照组,各25例。对照组予以血液透析治疗,研究组予以血液透析与血液灌流联合治疗。比较两组干预前后肾脏功能、炎症因子与血液净化指标。结果 治疗后,研究组血尿素氮(Blood Urea Nitrogen,BUN)[(10.99±4.19)mmol/L]、尿肌酐(Urine Creatinine,UCr)[(327.09±64.71)μmol/L]、血肌酐(Serum Creatinin,Scr)[(415.22±81.02)μmol/L]均低于对照组,差异有统计学意义(t=2.935、2.297、2.528,P均<0.05)。治疗后,研究组白细胞介素6(Interleukin-6,IL-6)、C反应蛋白(C-reactive Protein,CRP)、肿瘤坏死因子α(Tumour Necrosis Factor-α,TNF-α)水平低于对照组,差异有统计学意义(P均<0.05)。治疗后,研究组同型半胱氨酸(Homocysteine,Hcy)、甲状旁腺素(Parathyroid Hormone,PTH)与β2微球蛋白(β2 Microglobulin,β2-MG)水平低于对照组,差异有统计学意义(P均<0.05)。结论 尿毒症患者采用血液透析与血液灌流联合治疗,疗效显著。该疗法不仅对肾功能和炎症都有很好的改善效果,而且能很好地净化血液,有较高的临床应用价值。

Objective To investigate the efficacy of hemoperfusion combined with hemodialysis treatment in patients with uremia.Methods 50 patients with uremia admitted to Dongying City Dongying District People's Hospital from March 2020 to March 2023 were selected as the study objects.They were divided into the study group and the control group according to the random number table method,with 25 cases in each group.The control group was treated with hemodialysis,and the study group was treated with the combination of hemodialysis and hemoperfusion.Renal function,inflammatory factors and blood purification indexes before and after intervention were compared between the two groups.Results Blood urea nitrogen [(10.99±4.19) mmol/L],urine creatinine [(367.51±59.61) μmol/L],serum creatinin [(415.22±81.02) μmol/L] in the study group were lower than those in the control group after treatment,the differences were statistically significant(t=2.935,2.297,2.528,all P<0.05).Interleukin-6,C-reactive protein,and tumour necrosis factor-α levels in the study group were lower than those in the control group after treatment,the differences were statistically significant(all P<0.05).After treatment,homocysteine,parathyroid hormone,β2 microglobulin levels in the study group were lower than those in the control group,the differences were statistically significant(all P<0.05).Conclusion Patients with uremia treated with hemodialysis and hemoperfusion combined treatment has remarkable efficacy.This therapy can not only has a good improvement effect on both renal function and inflammation,but also purifies the blood well,which has certain clinical application value.