医院丙肝微消除模式的建立与应用成效

Establishment and application effect of micro-elimination model of hepatitis c in hospital

目的建立医院丙肝微消除模式并分析其在丙肝防治工作中的应用成效。方法以广西贵港市某三甲医院为例,通过部门分工、协调合作、能力建设多方面构建丙肝微消除模式,分析项目实施前(2021年)、项目实施后(2022年)两组抗-HCV筛查率、HCV RNA检测率、DAA治疗率、丙肝治愈人数的变化。结果2022年与2021年相比,抗-HCV筛查率由78.8%上升到81.2%,HCV RNA检测率由75.1%上升到97.8%,DAA治疗率由19.4%上升到57.3%,差异均具有统计学意义(P<0.05);丙肝治愈人数由61人上升到231人,成效明显。结论在医院建立丙肝微消除模式可显著提高抗-HCV筛查率、HCV RNA检测率、DAA治疗率,促进更多丙肝患者的治愈,有助于加快中国丙肝消除战略的进程,值得推广应用。

Objective To establish a micro-elimination model of hepatitis C in hospital and analyze its application effect in hepatitis C prevention and control.Methods A tertiary hospital in Guigang,Guangxi was taken as an example to construct a micro-elimination model of hepatitis C through division of labor,coordination and cooperation,and capacity building.The changes of anti-HCV screening rates,HCV RNA testing rates,DAA treatment rates,and the number of patients cured before(2021)and after(2022)the implementation of the project were analyzed.Results Compared with 2021,anti-HCV screening rate increased from 78.8%to 81.2%,HCV RNA testing rate increased from 75.1%to 97.8%,DAA treatment rate increased from 19.4%to 57.3%,and the number of people cured increased from 61 to 231 in 2022.The differences were all statistically significant(P<0.05).Conclusion The establishment of hepatitis C micro-elimination model in hospitals can significantly improve the anti-HCV screening rate,HCV RNA detection rate,DAA treatment rate,promote the cure of more hepatitis C patients,and help to accelerate the process of hepatitis C elimination strategy in China,which is worthy of popularization and application.