康替唑胺在非结核分枝杆菌患者的应用管理

Application management of contezolid in non-tuberculous mycobacterium patients

目的分析康替唑胺对非结核分枝杆菌患者的有效性和安全性,并探讨其临床应用管理的方法,为临床合理应用提供参考。方法对非结核分枝杆菌肺病患者病例进行分析,患者在使用利奈唑胺等常用抗非结核分枝杆菌药物后出现下肢麻木、心率降低等不良反应,采用康替唑胺作为新治疗药物之一,观察治疗效果和不良反应。结果明确患者出现外周神经炎是由利奈唑胺引起,替换为康替唑胺治疗后,症状好转,肺部病灶吸收,未出现不良反应。有必要对康替唑胺开展研究者发起的临床研究,充实超说明书用药证据。结论康替唑胺具有与利奈唑胺相似的抗菌活性,且经过药物结构改造后,毒副作用更低,在非结核分枝杆菌治疗中有很好的应用前景,有望成为长期用药时利奈唑胺的替代药物。

Objective To analyze the efficacy and safety of Contezolid in patients with non-tuberculous mycobacterium,and explore the methods of clinical application management so as to provide reference for clinical rational application.Methods A case of a patient with non-tuberculous mycobacterium lung disease was analyzed.Adverse reactions such as lower limb numbness and decreased heart rate occurred after using common non-tuberculous mycobacterium drugs such as linezolid.Cantizolid was used as one of the new therapeutic drugs to observe the therapeutic effect and adverse reactions.Results It was confirmed that the peripheral neuritis was caused by linezolid.After treatment with contezolid,the symptoms improved,the lung lesions were absorbed,and no adverse reactions occurred.It is necessary to conduct investigator-initiated clinical trials of contezolid and enrich evidence of off-label drug use.Conclusion Contezolid has similar antibacterial activity to linezolid,and the toxic side effects are lower after drug structure modification.Contezolid has a good application prospect in the treatment of non-tuberculous mycobacterium,and can be used as an alternative to linezolid for long-term use.