桑麻二虫汤治疗社区获得性肺炎(风热犯肺证)临床研究

Observation on the Therapeutic Effect of Sangma Erchong decoction on Community Acquired Pneumonia Patients with syndrome of wind-heat invading lung

目的:评价桑麻二虫汤治疗社区获得性肺炎(CAP)(风热犯肺证)患者的疗效和安全性。方法:将2021年5月至2021年12月在我院治疗的116例CAP(风热犯肺证)患者随机分为治疗组(58例)和对照组(58例),对照组予以西医常规治疗,观察组在西医治疗基础上予以口服桑麻二虫汤,两组患者疗程均为7天。比较两组患者治疗的总有效率,发热、咳嗽、咯痰中医证候评分及肺部感染评分(CPIS),同时比较两组患者退热时间、咳嗽消失时间和咯痰消失时间,以及降钙素原(PCT)、白细胞计数(WBC)、C反应蛋白(CRP)水平,同时观察记录两组患者不良反应发生情况。结果:观察组患者的治疗总有效率明显高于对照组(P<0.05)。治疗后,两组患者的发热、咳嗽、咯痰评分与CPIS评分较治疗前均有降低(P<0.05),且观察组显著低于对照组(P<0.05);观察组患者的退热时间、咳嗽和咯痰消失时间均比对照组明显缩短(P<0.05);两组患者的WBC、CRP、PCT水平较治疗前均降低(P<0.05),且观察组上述指标明显低于对照组(P<0.05)。治疗组有1例患者初次口服中药后出现短暂头晕、恶心,测血压正常,休息后自行缓解,对照组无明显不良反应发生。结论:桑麻二虫汤治疗CAP(风热犯肺证)可以提高疗效,缩短病程,降低炎症因子水平,并且无明显不良反应发生。

Objective:To evaluate the efficacy and safety of Sangma Erchong decoction in the treatment of community-acquired pneumonia(CAP)patients with syndrome of wind-heat invading lung.Method:A total of 116patients with CAP(lung syndrome caused by wind and heat)treated in our hospital from May 2021to December 2021were divided into the treatment group(58cases)and the control group(58cases)according to the random number table method.The control group was given conventional western medicine treatment,and the observation group was treated with Sanma Erzhi decoction on the basis of western medicine treatment.The total effective rate,traditional Chinese medicine symptom scores of fever,cough,expectoration and pulmonary infection score(CPIS)were compared between the two groups.The antipyretic time,cough disappearance time and expectoration disappearance time,procalcitonin(PCT),white blood cell count(WBC)and C-reactive protein(CRP)levels were compared between the two groups.Meanwhile,the adverse reactions of the two groups were observed and recorded.Results:The total effective rate of the observation group was significantly higher than the control group(P<0.05).After treatment,the scores of fever,cough,expectoration and CPIS in the two groups were lower than those before treatment(P<0.05),and those in the observation group were significantly lower than those in the control group(P<0.05).The antipyretic time,cough and expectoration disappearance time of the observation group were significantly shorter than those of the control group(P<0.05).The levels of WBC,CRP and PCT in the two groups were lower than those before treatment(P<0.05),and those in the observation group were significantly lower than those in the control group(P<0.05).During the treatment period,one patient in the treatment group had transient dizziness and nausea after the first oral administration of traditional Chinese medicine,and the blood pressure was normal,which relieved spontaneously after rest.No obvious adverse reactions occurred in the control group.Conclusion:Sangma Erchong Decoction in the treatment of CAP can improve the curative effect,shorten the course of disease,reduce the level of inflammatory factors,and has no obvious adverse reactions.