百合知母方结合针刺百会、神庭穴对永久性造口严重抑郁症(肝气郁结型)患者临床影响研究

Clinical effect of Baihe Zhimu Prescription combined with acupuncture of Baihui and Shenting points on patients with permanent stomostomy severe depression(Liver qi stagnation type)

目的:观察百合知母方结合针刺百会、神庭穴对永久性造口严重抑郁症(肝气郁结型)患者临床影响。方法:研究纳入永久性造口严重抑郁症(肝气郁结型)患者共计79例,将患者以随机数字表法分成对照组(39例)与观察组(40例),对照组患者给予阿戈美拉汀片药物干预及常规临床干预,观察组在对照组基础上给予患者百合知母方结合针刺百会、神庭穴干预,数据观察:疗效、干预前后患者中医证候(忧郁不畅、胸闷肋胀、失眠多梦、易怒善哭、嗳气频作、善太息等)积分变化、汉密尔顿抑郁量表(HAMD)及抑郁自评量表(SDS)评分变化、血清5-羟色胺(5-HT)及脑源性神经营养因子(BDNF)水平变化、不良反应。结果:观察组有效率(97.50%)比对照组(82.05%)更高,P<0.05;干预前,两组患者中医证候(忧郁不畅、胸闷肋胀、失眠多梦、易怒善哭、嗳气频作、善太息等)积分、HAMD及SDS评分、5-HT及BDNF水平比较,P>0.05,干预后各组患者中医证候(忧郁不畅、胸闷肋胀、失眠多梦、易怒善哭、嗳气频作、善太息等)积分、HAMD及SDS评分、5-HT及BDNF水平均改善,观察组患者干预后中医证候(忧郁不畅、胸闷肋胀、失眠多梦、易怒善哭、嗳气频作、善太息等)积分、HAMD及SDS评分、5-HT及BDNF水平等指标均优于对照组患者,P<0.05;两组均未见不良反应。结论:百合知母方结合针刺百会、神庭穴可较好改善永久性造口严重抑郁症(肝气郁结型)患者临床症状,提升临床疗效,促进患者病情好转,值得应用。

Objective:To observe the clinical effects of Baihe Zhimu prescription combined with acupuncture at Baihui and Shenting points on patients with permanent stoma severe depression(liver-qi stagnation type).Methods:Research into the permanent colostomy severe depression(diseases with ease)in patients with a total of 79cases,the patients with random number table method were divided into control group(39cases)and observation group(40cases)and control group patients give argonaut Melanesia dean drug intervention and routine clinical intervention,observation group in the control group on the basis of giving lily rhizoma anemarrhenae patients combined with acupuncture will best,god court den intervention,Data observation:Efficacy,TCM syndrome before and after the intervention patients(blue rib impeded,bosom frowsty,insomnia,much dream,irritability good cry,belching frequency,good heave a deep sigh,etc.)change,Hamilton depression rating scale(HAMD)and depression self rating scale(SDS)score changes,serum levels of serotonin(5-HT)and brain derived neurotrophic factor(BDNF)level changes and adverse reactions.Results:The effective rate of observation group(97.50%)was higher than that of control group(82.05%),P<0.05;Before intervention,the scores of TCM syndrome(depression,chest tightness,abdominal distension,insomnia and dreams,irritability and crying,belching frequency,good apexia,etc.),HAMD and SDS scores,5-HT and BDNF levels of 2groups were compared,P>0.05.After intervention,TCM syndrome scores,HAMD and SDS scores,5-HT and BDNF levels of patients in each group were improved.After intervention,the scores of TCM syndromes(depression,chest tightness and ribosomal distension,insomnia and many dreams,irritability and crying,belching frequency,good breath,etc.),HAMD and SDS scores,5-HT and BDNF levels in observation group were better than those in control group,P<0.05;No adverse reactions observed in both groups.Conclusion:Baihe Zhimu prescription combined with acupuncture at Baihui and Shenting points can better improve the clinical symptoms of patients with permanent stomostomy severe depression(liver qi stagnation type),improve the clinical efficacy and promote the improvement of patients'condition,which is worthy of application.