甘麦大枣汤加减联合雌激素片治疗围绝经期综合征33例

Clinical effect of modified Ganmai Dazao decoction combined with estrogen tablets in treatment of perimenopausal syndrome:An analysis of 33 cases

目的:观察甘麦大枣汤加减联合雌激素片对围绝经期综合征(PMS)患者症状及性激素水平的影响。方法:将66例PMS患者按照随机数字表法分为治疗组与对照组,每组各33例。对照组予以雌激素片治疗,治疗组在对照组的基础上加用予以甘麦大枣汤加减治疗。观察2组治疗前后中医证候各项评分、Kupperman评分、性激素水平[促卵泡生成素(FSH)、促黄体生成素(LH)、雌二醇(E2)]、氧化应激指标[丙二醇(MDA)、超氧化物歧化酶(SOD)]、不良反应发生情况,并评价临床疗效。结果:总有效率治疗组为93.94%(31/33),显著高于对照组的75.76%(25/33),差异有统计学意义(P<0.05)。2组中医证候各项评分、Kupperman评分、性激素及氧化应激各项指标治疗前后组内比较及治疗后组间比较,差异均有统计学意义(P<0.05)。2组不良反应总发生率组间比较,差异无统计学意义(P>0.05)。结论:甘麦大枣汤加减联合雌激素片对PMS患者有较好疗效,能够显著改善患者症状及性激素水平,减轻氧化应激反应,同时具有较高安全性。

Objective:To investigate the effect of modified Ganmai Dazao decoction combined with estrogen tablets on the symptoms and sex hormone levels of patients with perimenopausal syndrome(PMS).Methods:A total of 66 patients were divided into treatment group and control group using a random number table,with 33 patients in each group.The patients in the control group received estrogen tablets,and those in the treatment group received modified Ganmai Dazao decoction in addition to the treatment in the control group.The two groups were observed in terms of traditional Chinese medicine(TCM)syndrome score,Kupperman score,sex hormone levels(follicle-stimulating hormone,luteinizing hormone,and estradiol),oxidative stress indices(malondialdehyde and superoxide dismutase),and adverse reactions,and clinical outcome was also evaluated.Results:The treatment group had a significantly higher overall response rate than the control group[93.94%(31/33)vs 75.76%(25/33),P<0.05].After treatment,both groups had significant changes in TCM syndrome score,Kupperman score,sex hormone levels,and oxidative stress indices,and there were significant differences in these indicators between the two groups after treatment(P<0.05).There was no significant difference in the incidence rate of adverse reactions between the two groups(P>0.05).Conclusion:Modified Ganmai Dazao decoction combined with estrogen tablets has a marked effect in patients with PMS and can significantly improve their symptoms and sex hormone levels and alleviate oxidative stress response,with a favorable safety profile.